2hpd

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[[Image:2hpd.jpg|left|200px]]
[[Image:2hpd.jpg|left|200px]]
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{{Structure
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|PDB= 2hpd |SIZE=350|CAPTION= <scene name='initialview01'>2hpd</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2hpd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Unspecific_monooxygenase Unspecific monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.14.1 1.14.14.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2hpd| PDB=2hpd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpd OCA], [http://www.ebi.ac.uk/pdbsum/2hpd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hpd RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S'''
'''CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S'''
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[[Category: Peterson, J A.]]
[[Category: Peterson, J A.]]
[[Category: Ravichandran, K G.]]
[[Category: Ravichandran, K G.]]
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[[Category: oxidoreductase(oxygenase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:32:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:33:29 2008''
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Revision as of 03:32, 4 May 2008

Image:2hpd.jpg

Template:STRUCTURE 2hpd

CRYSTAL STRUCTURE OF HEMOPROTEIN DOMAIN OF P450BM-3, A PROTOTYPE FOR MICROSOMAL P450'S


Overview

Cytochrome P450BM-3, a bacterial fatty acid monoxygenase, resembles the eukaryotic microsomal P450's and their flavoprotein reductase in primary structure and function. The three-dimensional structure of the hemoprotein domain of P450BM-3 was determined by x-ray diffraction and refined to an R factor of 16.9 percent at 2.0 angstrom resolution. The structure consists of an alph and a beta domain. The active site heme is accessible through a long hydrophobic channel formed primarily by the beta domain and the B' and F helices of the alpha domain. The two molecules in the asymmetric unit differ in conformation around the substrate binding pocket. Substantial differences between P450BM-3 and P450cam, the only other P450 structure available, are observed around the substrate binding pocket and the regions important for redox partner binding. A general mechanism for proton transfer in P450's is also proposed.

About this Structure

2HPD is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's., Ravichandran KG, Boddupalli SS, Hasermann CA, Peterson JA, Deisenhofer J, Science. 1993 Aug 6;261(5122):731-6. PMID:8342039 Page seeded by OCA on Sun May 4 06:32:48 2008

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