2hsg

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[[Image:2hsg.jpg|left|200px]]
[[Image:2hsg.jpg|left|200px]]
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{{Structure
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|PDB= 2hsg |SIZE=350|CAPTION= <scene name='initialview01'>2hsg</scene>, resolution 2.500&Aring;
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The line below this paragraph, containing "STRUCTURE_2hsg", creates the "Structure Box" on the page.
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|GENE= ccpA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1404 Bacillus megaterium])
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{{STRUCTURE_2hsg| PDB=2hsg | SCENE= }}
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|RELATEDENTRY=[[1rzr|1RZR]], [[1sxg|1SXG]], [[1sxh|1SXH]], [[1shi|1SHI]], [[1zvv|1ZVV]], [[2fep|2FEP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hsg OCA], [http://www.ebi.ac.uk/pdbsum/2hsg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hsg RCSB]</span>
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'''Structure of transcription regulator CcpA in its DNA-free state'''
'''Structure of transcription regulator CcpA in its DNA-free state'''
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[[Category: Loll, B.]]
[[Category: Loll, B.]]
[[Category: Saenger, W.]]
[[Category: Saenger, W.]]
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[[Category: ccpa]]
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[[Category: Ccpa]]
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[[Category: transcriptional regulator]]
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[[Category: Transcriptional regulator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:39:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:34:50 2008''
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Revision as of 03:39, 4 May 2008

Template:STRUCTURE 2hsg

Structure of transcription regulator CcpA in its DNA-free state


Overview

The catabolite control protein A (CcpA) from Bacillus megaterium is a member of the bacterial repressor protein family GalR-LacI. CcpA functions as master transcriptional regulator of carbon catabolite repression/regulation in firmicutes. Here we present the crystal structure of full-length apo CcpA at 2.5 A resolution from B. megaterium. The structure reveals the location of the helix-turn-helix domain as well as the hinge region, which were not visible due to their high flexibility in earlier crystallographic studies on CcpA molecules. The structure of the apo CcpA homodimer in the present form is in contrast to other reported structures for CcpA.

About this Structure

2HSG is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.

Reference

Structure of full-length transcription regulator CcpA in the apo form., Loll B, Saenger W, Biesiadka J, Biochim Biophys Acta. 2007 Jun;1774(6):732-6. Epub 2007 Apr 18. PMID:17500051 Page seeded by OCA on Sun May 4 06:39:28 2008

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