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2hth

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[[Image:2hth.jpg|left|200px]]
[[Image:2hth.jpg|left|200px]]
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{{Structure
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|GENE= RPS27A, UBA52, UBB, UBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), VPS36, C13orf9, EAP45 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2hth| PDB=2hth | SCENE= }}
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|RELATEDENTRY=[[2cay|2CAY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hth FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hth OCA], [http://www.ebi.ac.uk/pdbsum/2hth PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hth RCSB]</span>
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'''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''
'''Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain'''
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[[Category: Sundquist, W I.]]
[[Category: Sundquist, W I.]]
[[Category: Whitby, F G.]]
[[Category: Whitby, F G.]]
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[[Category: glue domain]]
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[[Category: Glue domain]]
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[[Category: ph domain]]
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[[Category: Ph domain]]
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[[Category: protein sorting]]
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[[Category: Protein sorting]]
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[[Category: ubiquitin complex]]
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[[Category: Ubiquitin complex]]
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[[Category: viral budding]]
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[[Category: Viral budding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:41:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:12 2008''
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Revision as of 03:41, 4 May 2008

Image:2hth.jpg

Template:STRUCTURE 2hth

Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain


Overview

The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.

About this Structure

2HTH is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain., Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI, Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:17057716 Page seeded by OCA on Sun May 4 06:41:26 2008

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