2hua

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2hua.gif|left|200px]]
[[Image:2hua.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2hua |SIZE=350|CAPTION= <scene name='initialview01'>2hua</scene>
+
The line below this paragraph, containing "STRUCTURE_2hua", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2hua| PDB=2hua | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hua FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hua OCA], [http://www.ebi.ac.uk/pdbsum/2hua PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hua RCSB]</span>
+
-
}}
+
'''Solution Structure of CSFV IRES Domain IIa'''
'''Solution Structure of CSFV IRES Domain IIa'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
2HUA is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUA OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HUA OCA].
==Reference==
==Reference==
HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly., Locker N, Easton LE, Lukavsky PJ, EMBO J. 2007 Feb 7;26(3):795-805. Epub 2007 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17255934 17255934]
HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly., Locker N, Easton LE, Lukavsky PJ, EMBO J. 2007 Feb 7;26(3):795-805. Epub 2007 Jan 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17255934 17255934]
-
[[Category: Protein complex]]
 
[[Category: Easton, L E.]]
[[Category: Easton, L E.]]
[[Category: Locker, N.]]
[[Category: Locker, N.]]
[[Category: Lukavsky, P J.]]
[[Category: Lukavsky, P J.]]
-
[[Category: rna hairpin]]
+
[[Category: Rna hairpin]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:43:17 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:29 2008''
+

Revision as of 03:43, 4 May 2008

Image:2hua.gif

Template:STRUCTURE 2hua

Solution Structure of CSFV IRES Domain IIa


Overview

Internal ribosome entry site (IRES) RNAs from the hepatitis C virus (HCV) and classical swine fever virus (CSFV) coordinate cap-independent assembly of eukaryotic 48S initiation complexes, consisting of the 40S ribosomal subunit, eukaryotic initiation factor (eIF) 3 and the eIF2/GTP/Met-tRNA(i)(Met) ternary complex. Here, we report that these IRESes also play a functional role during 80S ribosome assembly downstream of 48S complex formation, in promoting eIF5-induced GTP hydrolysis and eIF2/GDP release from the initiation complex. We show that this function is encoded in their independently folded IRES domain II and that it depends both on its characteristic bent conformation and two conserved RNA motifs, an apical hairpin loop and a loop E. Our data suggest a general mode of subunit joining in HCV and HCV-like IRESes.

About this Structure

Full crystallographic information is available from OCA.

Reference

HCV and CSFV IRES domain II mediate eIF2 release during 80S ribosome assembly., Locker N, Easton LE, Lukavsky PJ, EMBO J. 2007 Feb 7;26(3):795-805. Epub 2007 Jan 25. PMID:17255934 Page seeded by OCA on Sun May 4 06:43:17 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hua"
Personal tools