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6d7l
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | The entry | + | ==Cytoplasmic domain of TRPC3== |
| - | + | <StructureSection load='6d7l' size='340' side='right' caption='[[6d7l]], [[Resolution|resolution]] 4.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d7l]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D7L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D7L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d7l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d7l OCA], [http://pdbe.org/6d7l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d7l RCSB], [http://www.ebi.ac.uk/pdbsum/6d7l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d7l ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/TRPC3_HUMAN TRPC3_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TRPC3_HUMAN TRPC3_HUMAN]] Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.<ref>PMID:20095964</ref> <ref>PMID:8646775</ref> <ref>PMID:9417057</ref> <ref>PMID:9930701</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Azumaya, C M]] | ||
| + | [[Category: Cordero-Morales, J F]] | ||
| + | [[Category: Nakagawa, T]] | ||
| + | [[Category: Sierra-Valdez, F J]] | ||
| + | [[Category: Cerebellum]] | ||
| + | [[Category: Ion channel]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Moonwalker]] | ||
| + | [[Category: Transport protein]] | ||
| + | [[Category: Trp channel]] | ||
Revision as of 07:27, 29 August 2018
Cytoplasmic domain of TRPC3
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