2hvd

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[[Image:2hvd.gif|left|200px]]
[[Image:2hvd.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hvd |SIZE=350|CAPTION= <scene name='initialview01'>2hvd</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_2hvd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= NME1, NDPKA, NM23 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2hvd| PDB=2hvd | SCENE= }}
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|RELATEDENTRY=[[2hve|2HVE]], [[1ucn|1UCN]], [[1jxv|1JXV]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvd OCA], [http://www.ebi.ac.uk/pdbsum/2hvd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hvd RCSB]</span>
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}}
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'''Human nucleoside diphosphate kinase A complexed with ADP'''
'''Human nucleoside diphosphate kinase A complexed with ADP'''
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[[Category: Giraud, M F.]]
[[Category: Giraud, M F.]]
[[Category: Lascu, I.]]
[[Category: Lascu, I.]]
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[[Category: complex adp]]
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[[Category: Complex adp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:45:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:55 2008''
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Revision as of 03:45, 4 May 2008

Image:2hvd.gif

Template:STRUCTURE 2hvd

Human nucleoside diphosphate kinase A complexed with ADP


Overview

Nm23 was the first metastasis suppressor gene identified. This gene encodes a NDP kinase that also exhibits other properties like histidine protein kinase and interactions with proteins and DNA. The S120G mutant of NDPK-A has been identified in aggressive neuroblastomas and has been found to reduce the metastasis suppressor effect of Nm23. In order to understand the differences between the wild type and the S120G mutant, we have determined the structure of both mutant and wild type NDPK-A in complex with ADP. Our results reveal that there are no significant changes between the two enzyme versions even in the surroundings of the catalytic histidine that is required for NDP kinase activity. This suggests that the S120G mutation may affect an other protein property than NDP kinase activity.

About this Structure

2HVD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structures of S120G mutant and wild type of human nucleoside diphosphate kinase A in complex with ADP., Giraud MF, Georgescauld F, Lascu I, Dautant A, J Bioenerg Biomembr. 2006 Aug;38(3-4):261-4. Epub 2006 Sep 1. PMID:16944299 Page seeded by OCA on Sun May 4 06:45:26 2008

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