6dbs
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Fusion surface structure, function, and dynamics of gamete fusogen HAP2== | |
| - | + | <StructureSection load='6dbs' size='340' side='right' caption='[[6dbs]], [[Resolution|resolution]] 2.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dbs]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DBS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DBS FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dbs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dbs OCA], [http://pdbe.org/6dbs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dbs RCSB], [http://www.ebi.ac.uk/pdbsum/6dbs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dbs ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HAP2_CHLRE HAP2_CHLRE]] During fertilization, required on male (minus) gametes for their fusion with female (plus) gametes (PubMed:18367645, PubMed:20335357, PubMed:25655701, PubMed:28235200). Required for membrane fusion, but not for the initial adhesion between gametes (PubMed:18367645, PubMed:25655701, PubMed:28235200). Inserts (via its extracellular domain) into lipid membranes (in vitro) (PubMed:28235200). Probably initiates the fusion of gamete cell membranes by inserting its extracellular domain into the cell membrane of a female gamete (PubMed:28235200).<ref>PMID:18367645</ref> <ref>PMID:20335357</ref> <ref>PMID:25655701</ref> <ref>PMID:28235200</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Dong, X]] | ||
| + | [[Category: Feng, J]] | ||
| + | [[Category: Springer, T A]] | ||
| + | [[Category: Cell fusogen]] | ||
| + | [[Category: Class ii fusion protein]] | ||
| + | [[Category: Gamete fertilization]] | ||
| + | [[Category: Hydrogen deuterium exchange]] | ||
| + | [[Category: Structural protein]] | ||
Revision as of 19:49, 19 September 2018
Fusion surface structure, function, and dynamics of gamete fusogen HAP2
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