6gfa
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed== | |
| - | + | <StructureSection load='6gfa' size='340' side='right'caption='[[6gfa]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6gfa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GFA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GFA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gfa OCA], [http://pdbe.org/6gfa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gfa RCSB], [http://www.ebi.ac.uk/pdbsum/6gfa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gfa ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/HS105_HUMAN HS105_HUMAN]] Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).[UniProtKB:Q60446][UniProtKB:Q61699]<ref>PMID:24318877</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Briand, L]] | ||
| + | [[Category: Garrido, C]] | ||
| + | [[Category: Gonzalez, D]] | ||
[[Category: Gotthard, G]] | [[Category: Gotthard, G]] | ||
| - | [[Category: | + | [[Category: Gozzi, G J]] |
[[Category: Neiers, F]] | [[Category: Neiers, F]] | ||
| - | [[Category: Briand, L]] | ||
| - | [[Category: Gozzi, G.J]] | ||
[[Category: Seigneuric, R]] | [[Category: Seigneuric, R]] | ||
| - | [[Category: | + | [[Category: Chaperone]] |
| + | [[Category: Hsp105]] | ||
| + | [[Category: Hsp110]] | ||
| + | [[Category: Hsp110de9]] | ||
| + | [[Category: Hsph1]] | ||
| + | [[Category: Nucleotide-binding domain]] | ||
Revision as of 11:16, 10 May 2019
Structure of Nucleotide binding domain of HSP110, ATP and Mg2+ complexed
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Categories: Large Structures | Briand, L | Garrido, C | Gonzalez, D | Gotthard, G | Gozzi, G J | Neiers, F | Seigneuric, R | Chaperone | Hsp105 | Hsp110 | Hsp110de9 | Hsph1 | Nucleotide-binding domain
