6d12
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA== | |
| - | + | <StructureSection load='6d12' size='340' side='right' caption='[[6d12]], [[Resolution|resolution]] 2.21Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6d12]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D12 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6D12 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6d12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d12 OCA], [http://pdbe.org/6d12 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6d12 RCSB], [http://www.ebi.ac.uk/pdbsum/6d12 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6d12 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN]] Microcephalic primordial dwarfism, Alazami type. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LARP7_HUMAN LARP7_HUMAN]] Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.<ref>PMID:18249148</ref> <ref>PMID:18483487</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cascio, D]] | ||
| + | [[Category: Eichhorn, C D]] | ||
[[Category: Feigon, J]] | [[Category: Feigon, J]] | ||
| - | [[Category: | + | [[Category: Sawaya, M R]] |
| - | [[Category: | + | [[Category: Rna apical loop]] |
| - | [[Category: | + | [[Category: Rna binding protein-rna complex]] |
| + | [[Category: Rna recognition motif]] | ||
| + | [[Category: Rrm]] | ||
Revision as of 05:37, 27 June 2018
Crystal structure of C-terminal xRRM domain of human Larp7 bound to 7SK stem-loop 4 RNA
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