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2i6s
From Proteopedia
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[[Image:2i6s.gif|left|200px]] | [[Image:2i6s.gif|left|200px]] | ||
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'''Complement component C2a''' | '''Complement component C2a''' | ||
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[[Category: Schouten, A.]] | [[Category: Schouten, A.]] | ||
[[Category: Vandeputte, D A.A.]] | [[Category: Vandeputte, D A.A.]] | ||
| - | [[Category: | + | [[Category: Serine protease domain]] |
| - | [[Category: | + | [[Category: Von willebrand factor-a domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:08:49 2008'' | |
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Revision as of 04:08, 4 May 2008
Complement component C2a
Overview
C2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal structures of full-length C2a, with and without a pseudo ligand bound. Both structures reveal a near-active conformation of the catalytic center of the serine protease domains, while the von Willebrand factor A-type domains display an intermediate activation state of helix alpha7 with an open, activated metal-ion-dependent adhesion site. The open adhesion site likely serves to enhance the affinity for the ligand C4b, similar to "inside-out" signaling in integrins. Surprisingly, the N-terminal residues of C2a are buried in a crevice near helix alpha7, indicative of a structural switch between C2 and C2a. Extended loops on the protease domain possibly envelop the protruding anaphylatoxin domain of the substrate C3. Together with a putative substrate-induced completion of the oxyanion hole, this may contribute to the high substrate specificity of the convertases.
About this Structure
2I6S is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of complement component C2A: implications for convertase formation and substrate binding., Milder FJ, Raaijmakers HC, Vandeputte MD, Schouten A, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P, Structure. 2006 Oct;14(10):1587-97. PMID:17027507 Page seeded by OCA on Sun May 4 07:08:49 2008
Categories: Classical-complement-pathway C3/C5 convertase | Homo sapiens | Single protein | Daha, M R. | Gros, P. | Hemrika, W. | Huizinga, E G. | Milder, F J. | Raaijmakers, H C.A. | Romijn, R A. | Roos, A. | Schouten, A. | Vandeputte, D A.A. | Serine protease domain | Von willebrand factor-a domain
