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4m6g

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==Structure of the Mycobacterium tuberculosis peptidoglycan amidase Rv3717 in complex with L-Alanine-iso-D-Glutamine reaction product==
==Structure of the Mycobacterium tuberculosis peptidoglycan amidase Rv3717 in complex with L-Alanine-iso-D-Glutamine reaction product==
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<StructureSection load='4m6g' size='340' side='right' caption='[[4m6g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='4m6g' size='340' side='right'caption='[[4m6g]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4m6g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4M6G FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4m6g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M6G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4M6G FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=ZGL:D-ALPHA-GLUTAMINE'>ZGL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=ZGL:D-ALPHA-GLUTAMINE'>ZGL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4m6h|4m6h]], [[4m6i|4m6i]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4m6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6g OCA], [https://pdbe.org/4m6g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4m6g RCSB], [https://www.ebi.ac.uk/pdbsum/4m6g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6g ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv3717 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/N-acetylmuramoyl-L-alanine_amidase N-acetylmuramoyl-L-alanine amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4m6g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4m6g OCA], [http://pdbe.org/4m6g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4m6g RCSB], [http://www.ebi.ac.uk/pdbsum/4m6g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4m6g ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PEPAM_MYCTU PEPAM_MYCTU]] Cell-wall hydrolase that hydrolyzes the amide bond between N-acetylmuramic acid and L-alanine in cell-wall glycopeptides (PubMed:24311595, PubMed:24019530). Is able to hydrolyze the cell walls of several bacterial species (i.e. Paenibacillus sp., B.avium, E.coli DH5alpha, E.aerogenes, L.acidophilus, B.thuringiensis, B.pumilus, B.subtilis and E.coli W3110), thereby showing that it is a cell-wall hydrolase with broad-spectrum activity (PubMed:24311595). May have a role in peptidoglycan fragment recycling (PubMed:24019530).<ref>PMID:24019530</ref> <ref>PMID:24311595</ref>
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[https://www.uniprot.org/uniprot/O69684_MYCTO O69684_MYCTO]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: N-acetylmuramoyl-L-alanine amidase]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Alber, T]]
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[[Category: Alber T]]
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[[Category: Huizar, J P]]
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[[Category: Huizar JP]]
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[[Category: Mavrici, D]]
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[[Category: Mavrici D]]
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[[Category: Prigozhin, D M]]
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[[Category: Prigozhin DM]]
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[[Category: Structural genomic]]
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[[Category: Vansell HJ]]
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[[Category: Vansell, H J]]
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[[Category: Hydrolase]]
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[[Category: National institute of allergy and infectious disease]]
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[[Category: Niaid]]
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[[Category: Tbsgc]]
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[[Category: Zn binding]]
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Revision as of 10:59, 21 December 2022

Structure of the Mycobacterium tuberculosis peptidoglycan amidase Rv3717 in complex with L-Alanine-iso-D-Glutamine reaction product

PDB ID 4m6g

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