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5ypk

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Current revision (08:34, 22 November 2023) (edit) (undo)
 
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==Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex==
==Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex==
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<StructureSection load='5ypk' size='340' side='right' caption='[[5ypk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5ypk' size='340' side='right'caption='[[5ypk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ypk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YPK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5YPK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ypk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YPK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HIW:(2R,4S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-[(2-{[(Z)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>HIW</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">blaNDM-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HIW:(2R,4S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-[(2-{[(Z)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-3,4-DIHYDRO-2H-PYRROLE-5-CARBOXYLIC+ACID'>HIW</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ypk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ypk OCA], [http://pdbe.org/5ypk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ypk RCSB], [http://www.ebi.ac.uk/pdbsum/5ypk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ypk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ypk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ypk OCA], [https://pdbe.org/5ypk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ypk RCSB], [https://www.ebi.ac.uk/pdbsum/5ypk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ypk ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/E5KIY2_ECOLX E5KIY2_ECOLX]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Beta-lactamase|Beta-lactamase]]
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*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
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[[Category: Feng, H]]
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[[Category: Large Structures]]
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[[Category: Liu, W]]
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[[Category: Feng H]]
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[[Category: Wang, D]]
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[[Category: Liu W]]
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[[Category: Ei2 complex]]
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[[Category: Wang D]]
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[[Category: Hydrolase]]
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[[Category: Imipenem]]
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[[Category: Ndm-1]]
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Current revision

Crystal structure of NDM-1 bound to hydrolyzed imipenem representing an EI2 complex

PDB ID 5ypk

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