6cfz
From Proteopedia
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cfz OCA], [http://pdbe.org/6cfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cfz RCSB], [http://www.ebi.ac.uk/pdbsum/6cfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cfz ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6cfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6cfz OCA], [http://pdbe.org/6cfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6cfz RCSB], [http://www.ebi.ac.uk/pdbsum/6cfz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6cfz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Kinetochores connect mitotic-spindle microtubules with chromosomes, allowing microtubule depolymerization to pull chromosomes apart during anaphase while resisting detachment as the microtubule shortens. The heterodecameric DASH/Dam1 complex (DASH/Dam1c), an essential component of yeast kinetochores, assembles into a microtubule-encircling ring. The ring associates with rodlike Ndc80 complexes to organize the kinetochore-microtubule interface. We report the cryo-electron microscopy structure (at ~4.5-angstrom resolution) of a DASH/Dam1c ring and a molecular model of its ordered components, validated by evolutionary direct-coupling analysis. Integrating this structure with that of the Ndc80 complex and with published interaction data yields a molecular picture of kinetochore-microtubule attachment, including how flexible, C-terminal extensions of DASH/Dam1c subunits project and contact widely separated sites on the Ndc80 complex rod and how phosphorylation at previously identified sites might regulate kinetochore assembly. | ||
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| + | Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface.,Jenni S, Harrison SC Science. 2018 May 4;360(6388):552-558. doi: 10.1126/science.aar6436. PMID:29724956<ref>PMID:29724956</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6cfz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Revision as of 07:46, 23 May 2018
Structure of the DASH/Dam1 complex shows its role at the yeast kinetochore-microtubule interface
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Categories: Cbs 144 50 | Chatd | Harrison, S C | Jenni, S | Ask1 | Cell-division | Chromosome segregation | Dad1 | Dad2 | Dad3 | Dad4 | Dam1 | Dam1 complex | Dash | Duo1 | Hsk3 | Kinetochore | Kinetochore-microtubule interface | Nuclear protein | Point-centromere yeast | Spc19 | Spc34
