2i9s
From Proteopedia
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'''The solution structure of the core of mesoderm development (MESD).''' | '''The solution structure of the core of mesoderm development (MESD).''' | ||
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[[Category: Oschkinat, H.]] | [[Category: Oschkinat, H.]] | ||
[[Category: Schmieder, P.]] | [[Category: Schmieder, P.]] | ||
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Revision as of 04:14, 4 May 2008
The solution structure of the core of mesoderm development (MESD).
Overview
Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for receptors of the low-density lipoprotein receptor (LDLR) family. By recording (15)N-HSQC-NMR spectra of six different MESD constructs, we could determine a highly structured core region corresponding to residues 104-177. Here we firstly present the solution structure of this highly conserved core of MESD. It shows a four-stranded anti-parallel beta-sheet and two alpha-helices situated on one side of the sheet. Although described in the literature as structurally homologues to ferredoxins, the connectivity of secondary structure elements is different in the MESD fold. A structural comparison to entries of the PDB reveals a frequent domain with low sequence homology annotated as HMA and P-II domains in Pfam.
About this Structure
2I9S is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family., Kohler C, Andersen OM, Diehl A, Krause G, Schmieder P, Oschkinat H, J Struct Funct Genomics. 2006 Dec;7(3-4):131-8. Epub 2007 Mar 7. PMID:17342452 Page seeded by OCA on Sun May 4 07:14:04 2008
