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Estrogen receptor

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==Estrogen receptor α complexed with raloxifene and a corepressor peptide==
==Estrogen receptor α complexed with raloxifene and a corepressor peptide==
<scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]).
<scene name='Estrogen_receptor/Cv/1'>Click here to see the difference between conformations</scene> of estrogen receptor α complexed with raloxifene and a corepressor peptide (morph was taken from [http://molmovdb.org/cgi-bin/movie.cgi Gallery of Morphs] of the [http://molmovdb.org Yale Morph Server]).
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==3D structures of estrogen receptor==
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[[Estrogen receptor 3D structures]]
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</StructureSection>
</StructureSection>
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*Estrogen receptor α ligand binding domain residues 245-554
*Estrogen receptor α ligand binding domain residues 245-554
-
**[[4n1y]] - ERα LBD – pacific oyster<br />
 
**[[1a52]], [[1g50]] - hERα LBD - human<br />
**[[1a52]], [[1g50]] - hERα LBD - human<br />
**[[1ere]], [[1qku]] - hERα LBD + EST<BR />
**[[1ere]], [[1qku]] - hERα LBD + EST<BR />
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**[[2bj4]], [[2jf9]], [[2jfa]], [[1pcg]], [[5gtr]], [[5gs4]] - hERα LBD + peptide antagonist<br />
**[[2bj4]], [[2jf9]], [[2jfa]], [[1pcg]], [[5gtr]], [[5gs4]] - hERα LBD + peptide antagonist<br />
**[[2q6j]], [[2p15]], [[3erd]], [[1l2i]] - hERα LBD + GRIP peptide<br />
**[[2q6j]], [[2p15]], [[3erd]], [[1l2i]] - hERα LBD + GRIP peptide<br />
-
**[[6cbz]] - hERα LBD (mutant) + GRIP peptide + estradiol<br />
+
**[[6d0f]], [[6czn]] - hERα LBD (mutant) + GRIP peptide<br />
 +
**[[6cbz]], [[5wgq]], [[5wgd]] - hERα LBD (mutant) + GRIP peptide + estradiol<br />
**[[4q13]] - hERα LBD (mutant) + glucocorticoid receptor-interacting protein peptide<br />
**[[4q13]] - hERα LBD (mutant) + glucocorticoid receptor-interacting protein peptide<br />
**[[5krf]] - hERα LBD (mutant) + peptide + anti-hormone<br />
**[[5krf]] - hERα LBD (mutant) + peptide + anti-hormone<br />
**[[2yat]] - hERα LBD (mutant) + EST derivative<br />
**[[2yat]] - hERα LBD (mutant) + EST derivative<br />
 +
**[[6iar]], [[6dfn]], [[6df6]] - hERα LBD + antagonist<br />
**[[5fqp]], [[5fqr]], [[5fqs]], [[5fqt]], [[5fqv]], [[5aau]], [[5aav]], [[5acc]], [[5ak2]], [[5di7]], [[5did]], [[5die]], [[5dig]], [[5dk9]], [[5dkb]], [[5dke]], [[5dkg]], [[5dks]], [[5dl4]], [[5dlr]], [[5dmc]], [[5dmf]], [[5dp0]], [[6chz]], [[6chw]], [[6c42]], [[6b0f]], [[5w9d]], [[5ufx]], [[5ufw]] - hERα LBD (mutant) + antagonist<br />
**[[5fqp]], [[5fqr]], [[5fqs]], [[5fqt]], [[5fqv]], [[5aau]], [[5aav]], [[5acc]], [[5ak2]], [[5di7]], [[5did]], [[5die]], [[5dig]], [[5dk9]], [[5dkb]], [[5dke]], [[5dkg]], [[5dks]], [[5dl4]], [[5dlr]], [[5dmc]], [[5dmf]], [[5dp0]], [[6chz]], [[6chw]], [[6c42]], [[6b0f]], [[5w9d]], [[5ufx]], [[5ufw]] - hERα LBD (mutant) + antagonist<br />
-
**[[4q50]] - hERα LBD (mutant) + tamoxifen derivative<br />
+
**[[6owc]] - hERα LBD (mutant) + pyridine derivative<br />
 +
**[[4q50]], [[5w9c]] - hERα LBD (mutant) + tamoxifen derivative<br />
**[[3uuc]] - hERα LBD + bisphenol<br />
**[[3uuc]] - hERα LBD + bisphenol<br />
**[[5t1z]] - hERα LBD + LXXLL motif (mutant) + ethoxy triphenylethylene<br />
**[[5t1z]] - hERα LBD + LXXLL motif (mutant) + ethoxy triphenylethylene<br />
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**[[2yja]] - hERα LBD + NCAO2 peptide<br />
**[[2yja]] - hERα LBD + NCAO2 peptide<br />
**[[2b23]] - hERα LBD (mutant) + NCAO2 peptide<br />
**[[2b23]] - hERα LBD (mutant) + NCAO2 peptide<br />
 +
**[[4n1y]] - ERα LBD – pacific oyster<br />
*''ERα LBD ternary complex with nuclear receptor coactivator 2 peptide (NCAO2)''
*''ERα LBD ternary complex with nuclear receptor coactivator 2 peptide (NCAO2)''

Revision as of 10:11, 23 June 2019

Human estrogen receptor-ligand binding domain (grey) complex with transcription intermediate factor-2 peptide (pink) and estradiol (PDB code 1gwr)

Drag the structure with the mouse to rotate


For more details see

Ivan Koutsopatriy estrogen receptor
C-di-GMP receptors with PilZ domain
For more details on ERβ see Student Project 10 for UMass Chemistry 423 Spring 2015
For more details on ER-Tamoxifen complex see Tamoxifen.


3D structures of estrogen receptor

Updated on 23-June-2019


Reference

  1. ↑ Li MJ, Greenblatt HM, Dym O, Albeck S, Pais A, Gunanathan C, Milstein D, Degani H, Sussman JL. Structure of estradiol metal chelate and estrogen receptor complex: The basis for designing a new class of selective estrogen receptor modulators. J Med Chem. 2011 Apr 7. PMID:21473635 doi:10.1021/jm200192y

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman, Alexander Berchansky

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