5zt2
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of CCG DNA repeats at 1.66 angstrom resolution== | |
| + | <StructureSection load='5zt2' size='340' side='right'caption='[[5zt2]], [[Resolution|resolution]] 1.66Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5zt2]] is a 1 chain structure. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4qno 4qno]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZT2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZT2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zt2 OCA], [http://pdbe.org/5zt2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zt2 RCSB], [http://www.ebi.ac.uk/pdbsum/5zt2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zt2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | CCG triplet repeats can fold into tetraplex structures, which are associated with the expansion of (CCG)n trinucleotide sequences in certain neurological diseases. These structures are stabilized by intertwining i-motifs. However, the structural basis for tetraplex i-motif formation in CCG triplet repeats remains largely unknown. We report the first crystal structure of a CCG-repeat sequence, which shows that two dT(CCG)3 A strands can associate to form a tetraplex structure with an i-motif core containing four C:C(+) pairs flanked by two G:G homopurine base pairs as a structural motif. The tetraplex core is attached to a short parallel-stranded duplex. Each hairpin itself contains a central CCG loop in which the nucleotides are flipped out and stabilized by stacking interactions. The helical twists between adjacent cytosine residues of this structure in the i-motif core have an average value of 30 degrees , which is greater than those previously reported for i-motif structures. | ||
| - | + | Structural basis for the identification of an i-motif tetraplex core with a parallel-duplex junction as a structural motif in CCG triplet repeats.,Chen YW, Jhan CR, Neidle S, Hou MH Angew Chem Int Ed Engl. 2014 Sep 26;53(40):10682-6. doi: 10.1002/anie.201405637. , Epub 2014 Aug 19. PMID:25139267<ref>PMID:25139267</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5zt2" style="background-color:#fffaf0;"></div> |
| - | [[Category: Hou, M | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Wu, P | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen, Y W]] | ||
| + | [[Category: Hou, M H]] | ||
| + | [[Category: Satange, R B]] | ||
| + | [[Category: Wu, P C]] | ||
| + | [[Category: Dna]] | ||
| + | [[Category: Dna structure]] | ||
| + | [[Category: I-motif]] | ||
| + | [[Category: Neurological disease]] | ||
| + | [[Category: Tetraplex structure]] | ||
Revision as of 07:17, 21 May 2019
Crystal structure of CCG DNA repeats at 1.66 angstrom resolution
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