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2iep

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[[Image:2iep.gif|left|200px]]
[[Image:2iep.gif|left|200px]]
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{{Structure
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|PDB= 2iep |SIZE=350|CAPTION= <scene name='initialview01'>2iep</scene>, resolution 2.205&Aring;
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The line below this paragraph, containing "STRUCTURE_2iep", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
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|GENE= Musk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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{{STRUCTURE_2iep| PDB=2iep | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iep OCA], [http://www.ebi.ac.uk/pdbsum/2iep PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iep RCSB]</span>
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'''Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK'''
'''Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK'''
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[[Category: Hubbard, S R.]]
[[Category: Hubbard, S R.]]
[[Category: Stiegler, A L.]]
[[Category: Stiegler, A L.]]
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[[Category: beta-sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:25:13 2008''
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Revision as of 04:25, 4 May 2008

Image:2iep.gif

Template:STRUCTURE 2iep

Crystal structure of immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK


Overview

Muscle-specific kinase (MuSK) is a receptor tyrosine kinase expressed exclusively in skeletal muscle, where it is required for formation of the neuromuscular junction. MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. Here, we report the crystal structure of the agrin-responsive first and second immunoglobulin-like domains (Ig1 and Ig2) of the MuSK ectodomain at 2.2 A resolution. The structure reveals that MuSK Ig1 and Ig2 are Ig-like domains of the I-set subfamily, which are configured in a linear, semi-rigid arrangement. In addition to the canonical internal disulfide bridge, Ig1 contains a second, solvent-exposed disulfide bridge, which our biochemical data indicate is critical for proper folding of Ig1 and processing of MuSK. Two Ig1-2 molecules form a non-crystallographic dimer that is mediated by a unique hydrophobic patch on the surface of Ig1. Biochemical analyses of MuSK mutants introduced into MuSK(-/-) myotubes demonstrate that residues in this hydrophobic patch are critical for agrin-induced MuSK activation.

About this Structure

2IEP is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK., Stiegler AL, Burden SJ, Hubbard SR, J Mol Biol. 2006 Dec 1;364(3):424-33. Epub 2006 Sep 12. PMID:17011580 Page seeded by OCA on Sun May 4 07:25:13 2008

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