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| | ==The crystal structure of zebrafish IL-22== | | ==The crystal structure of zebrafish IL-22== |
| - | <StructureSection load='4o6k' size='340' side='right' caption='[[4o6k]], [[Resolution|resolution]] 2.10Å' scene=''> | + | <StructureSection load='4o6k' size='340' side='right'caption='[[4o6k]], [[Resolution|resolution]] 2.10Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4O6K FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4o6k]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4O6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4O6K FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">il22, IL-22 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [https://pdbe.org/4o6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [https://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4o6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4o6k OCA], [http://pdbe.org/4o6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4o6k RCSB], [http://www.ebi.ac.uk/pdbsum/4o6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4o6k ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/Q5TLE4_DANRE Q5TLE4_DANRE] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </div> | | </div> |
| | <div class="pdbe-citations 4o6k" style="background-color:#fffaf0;"></div> | | <div class="pdbe-citations 4o6k" style="background-color:#fffaf0;"></div> |
| | + | |
| | + | ==See Also== |
| | + | *[[Interleukin 3D structures|Interleukin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Brachidanio rerio]] | + | [[Category: Danio rerio]] |
| - | [[Category: Fretaud, M]] | + | [[Category: Large Structures]] |
| - | [[Category: Hamming, O J]] | + | [[Category: Fretaud M]] |
| - | [[Category: Hartmann, R]] | + | [[Category: Hamming OJ]] |
| - | [[Category: Levraud, J P]] | + | [[Category: Hartmann R]] |
| - | [[Category: Luftalla, G]] | + | [[Category: Levraud JP]] |
| - | [[Category: Siupka, P]] | + | [[Category: Luftalla G]] |
| - | [[Category: Il-22]]
| + | [[Category: Siupka P]] |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Interleukin-22]]
| + | |
| - | [[Category: Zil-22]]
| + | |
| Structural highlights
Function
Q5TLE4_DANRE
Publication Abstract from PubMed
The class II cytokine family consists of small alpha-helical signaling proteins including the interleukin-10 (IL-10)/IL-22 family, as well as interferons (IFNs). They regulate the innate immune response and in addition have an important role in protecting epithelial tissues. Teleost fish possess a class II cytokine system surprisingly similar to that of humans, and thus zebrafish offers an attractive model organism for investigating the role of class II cytokines in inflammation. However, the evolution of class II cytokines is critical to understand if we are to take full advantage of zebrafish as a model system. The small size and fast evolution of these cytokines obscure phylogenetic analyses based purely on sequences, but one can overcome this obstacle by using information contained within the structure of those molecules. Here we present the crystal structure of IL-22 from zebrafish (zIL-22) solved at 2.1 A, which displays a typical class II cytokine architecture. We generated a structure-guided alignment of vertebrate class II cytokines and used it for phylogenetic analysis. Our analysis suggests that IL-22 and IL-26 arose early during the evolution of the IL-10-like cytokines. Thus, we propose an evolutionary scenario of class II cytokines in vertebrates, based on genomic and structural data.
The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22.,Siupka P, Hamming OJ, Fretaud M, Luftalla G, Levraud JP, Hartmann R Genes Immun. 2014 Jul-Aug;15(5):293-302. doi: 10.1038/gene.2014.18. Epub 2014 May, 15. PMID:24833303[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Siupka P, Hamming OJ, Fretaud M, Luftalla G, Levraud JP, Hartmann R. The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22. Genes Immun. 2014 Jul-Aug;15(5):293-302. doi: 10.1038/gene.2014.18. Epub 2014 May, 15. PMID:24833303 doi:http://dx.doi.org/10.1038/gene.2014.18
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