2ihs

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[[Image:2ihs.jpg|left|200px]]
[[Image:2ihs.jpg|left|200px]]
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{{Structure
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|PDB= 2ihs |SIZE=350|CAPTION= <scene name='initialview01'>2ihs</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2ihs", creates the "Structure Box" on the page.
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|GENE= gus ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
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{{STRUCTURE_2ihs| PDB=2ihs | SCENE= }}
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|RELATEDENTRY=[[2fnj|2FNJ]], [[2fbe|2FBE]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ihs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ihs OCA], [http://www.ebi.ac.uk/pdbsum/2ihs PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ihs RCSB]</span>
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'''Crystal structure of the B30.2/SPRY domain of GUSTAVUS in complex with a 20-residue VASA peptide'''
'''Crystal structure of the B30.2/SPRY domain of GUSTAVUS in complex with a 20-residue VASA peptide'''
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[[Category: Park, S Y.]]
[[Category: Park, S Y.]]
[[Category: Woo, J S.]]
[[Category: Woo, J S.]]
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[[Category: b30 2/spry]]
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[[Category: B30 2/spry]]
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[[Category: f-box-spry]]
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[[Category: F-box-spry]]
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[[Category: gustavus]]
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[[Category: Gustavus]]
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[[Category: spry-containing socs box]]
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[[Category: Spry-containing socs box]]
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[[Category: trim family]]
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[[Category: Trim family]]
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[[Category: vasa]]
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[[Category: Vasa]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:31:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:44:31 2008''
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Revision as of 04:31, 4 May 2008

Image:2ihs.jpg

Template:STRUCTURE 2ihs

Crystal structure of the B30.2/SPRY domain of GUSTAVUS in complex with a 20-residue VASA peptide


Overview

B30.2/SPRY domains are found in numerous proteins that cover a wide spectrum of biological functions, including regulation of cytokine signaling and innate retroviral restriction. Herein, we report the crystal structure of the B30.2/SPRY domain of a SPRY domain-containing SOCS box (SSB) protein, GUSTAVUS, complexed with a 20 amino acid peptide derived from the RNA helicase VASA, revealing how these domains recognize target proteins. The peptide-binding site is conformationally rigid and has a preformed pocket. The interaction between the pocket and the Asp-Ile-Asn-Asn-Asn-Asn sequence within the peptide accounts for the high-affinity binding between GUSTAVUS and VASA. This observation led to a facile identification of the Glu-Leu-Asn-Asn-Asn-Leu sequence as the recognition motif in a proapoptotic protein Par-4 for its interaction with a GUSTAVUS homolog, SSB-1. Ensuing analyses indicated that many B30.2/SPRY domains have a similar preformed pocket, which would allow them to bind multiple targets.

About this Structure

2IHS is a Protein complex structure of sequences from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structural basis for protein recognition by B30.2/SPRY domains., Woo JS, Suh HY, Park SY, Oh BH, Mol Cell. 2006 Dec 28;24(6):967-76. PMID:17189197 Page seeded by OCA on Sun May 4 07:31:21 2008

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