This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2cry
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of the fifth ig-like domain of human kin of IRRE like 3== | ==Solution structure of the fifth ig-like domain of human kin of IRRE like 3== | ||
| - | <StructureSection load='2cry' size='340' side='right' caption='[[2cry]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cry' size='340' side='right'caption='[[2cry]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cry]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cry]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CRY FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIRREL3, KIAA1867, NEPH2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KIRREL3, KIAA1867, NEPH2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cry OCA], [https://pdbe.org/2cry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cry RCSB], [https://www.ebi.ac.uk/pdbsum/2cry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cry ProSAT], [https://www.topsan.org/Proteins/RSGI/2cry TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KIRR3_HUMAN KIRR3_HUMAN]] Note=A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4) [MIM:[https://omim.org/entry/612581 612581]]. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:19012874</ref> |
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/KIRR3_HUMAN KIRR3_HUMAN]] Could be involved in the hematopoietic supportive capacity of stroma cells (By similarity). |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 26: | Line 26: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Hayashi, F]] | [[Category: Hayashi, F]] | ||
[[Category: Kurosaki, C]] | [[Category: Kurosaki, C]] | ||
Revision as of 11:48, 3 February 2021
Solution structure of the fifth ig-like domain of human kin of IRRE like 3
| |||||||||||
