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2cud
From Proteopedia
(Difference between revisions)
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==Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)== | ==Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)== | ||
| - | <StructureSection load='2cud' size='340' side='right' caption='[[2cud]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2cud' size='340' side='right'caption='[[2cud]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cud]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2cud]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CUD FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLA ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SLA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cud OCA], [https://pdbe.org/2cud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cud RCSB], [https://www.ebi.ac.uk/pdbsum/2cud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cud ProSAT], [https://www.topsan.org/Proteins/RSGI/2cud TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/SLAP1_HUMAN SLAP1_HUMAN]] Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins.<ref>PMID:11696592</ref> <ref>PMID:10449770</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Inoue, M]] | [[Category: Inoue, M]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 11:50, 3 February 2021
Solution structure of the SH3 domain of the human SRC-like adopter protein (SLAP)
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Categories: Human | Large Structures | Inoue, M | Kigawa, T | Koshiba, S | Nameki, N | Ohnishi, S | Structural genomic | Sato, M | Tochio, N | Yokoyama, S | National project on protein structural and functional analyse | Negative mitogenesis regulator | Nppsfa | Rsgi | Sh3 domain | Signaling protein
