2ila

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2ila.gif|left|200px]]
[[Image:2ila.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2ila |SIZE=350|CAPTION= <scene name='initialview01'>2ila</scene>, resolution 2.3&Aring;
+
The line below this paragraph, containing "STRUCTURE_2ila", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND=
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2ila| PDB=2ila | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ila FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ila OCA], [http://www.ebi.ac.uk/pdbsum/2ila PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ila RCSB]</span>
+
-
}}
+
'''STRUCTURE OF INTERLEUKIN 1ALPHA AT 2.7-ANGSTROMS RESOLUTION'''
'''STRUCTURE OF INTERLEUKIN 1ALPHA AT 2.7-ANGSTROMS RESOLUTION'''
Line 27: Line 24:
[[Category: Graves, B J.]]
[[Category: Graves, B J.]]
[[Category: Hatada, M H.]]
[[Category: Hatada, M H.]]
-
[[Category: cytokine]]
+
[[Category: Cytokine]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:37:38 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:45:43 2008''
+

Revision as of 04:37, 4 May 2008

Image:2ila.gif

Template:STRUCTURE 2ila

STRUCTURE OF INTERLEUKIN 1ALPHA AT 2.7-ANGSTROMS RESOLUTION


Overview

The interleukin 1 (IL-1) family of proteins has a central role in modulating immune and inflammatory responses. Two major IL-1 proteins, designated alpha (IL-1 alpha) and beta (IL-1 beta), are produced by activated macrophages and other cell types. In an effort to understand the similarities and differences in the physicochemical and functional properties of these two proteins, a program was initiated to determine their structures. Crystals of IL-1 alpha were grown, and the three-dimensional structure at 2.7-A resolution was solved. The technique of multiple-wavelength anomalous dispersion (MAD) with the selenomethionine form of IL-1 alpha was utilized in combination with a single mercury derivative to provide the starting phases. Partial refinement of the IL-1 alpha model has been performed as well. The overall structure is composed of 14 beta-strands and a 3(10) helix. The core of this structure is a capped beta-barrell that possesses 3-fold symmetry and displays a topology similar to that observed for IL-1 beta [Priestle, J. P., et al. (1988) EMBO J. 7, 339-343] and soybean trypsin inhibitor (STI) [McLachlan, A. D. (1979) J. Mol. Biol. 133, 557-563]. In this paper, the overall structure of IL-1 alpha and the nature and fidelity of the internal 3-fold symmetry are discussed. Comparisons with IL-1 beta and STI are made within these contexts.

About this Structure

2ILA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of interleukin 1 alpha at 2.7-A resolution., Graves BJ, Hatada MH, Hendrickson WA, Miller JK, Madison VS, Satow Y, Biochemistry. 1990 Mar 20;29(11):2679-84. PMID:2346741 Page seeded by OCA on Sun May 4 07:37:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2ila"
Personal tools