2ilt

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[[Image:2ilt.jpg|left|200px]]
[[Image:2ilt.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ilt |SIZE=350|CAPTION= <scene name='initialview01'>2ilt</scene>, resolution 2.300&Aring;
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The line below this paragraph, containing "STRUCTURE_2ilt", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=NN1:2-(2-CHLORO-4-FLUOROPHENOXY)-2-METHYL-N-[(1R,2S,3S,5S,7S)-5-(METHYLSULFONYL)-2-ADAMANTYL]PROPANAMIDE'>NN1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/11-beta-hydroxysteroid_dehydrogenase 11-beta-hydroxysteroid dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.146 1.1.1.146] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HSD11B1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2ilt| PDB=2ilt | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ilt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ilt OCA], [http://www.ebi.ac.uk/pdbsum/2ilt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ilt RCSB]</span>
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}}
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'''Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor'''
'''Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor'''
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[[Category: Qin, W.]]
[[Category: Qin, W.]]
[[Category: Sorensen, B.]]
[[Category: Sorensen, B.]]
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[[Category: hsd1]]
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[[Category: Hsd1]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: nadp]]
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[[Category: Nadp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:38:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:45:48 2008''
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Revision as of 04:38, 4 May 2008

Image:2ilt.jpg

Template:STRUCTURE 2ilt

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor


Contents

Overview

Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.

Disease

Known disease associated with this structure: Cortisone reductase deficiency OMIM:[600713]

About this Structure

2ILT is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors., Sorensen B, Winn M, Rohde J, Shuai Q, Wang J, Fung S, Monzon K, Chiou W, Stolarik D, Imade H, Pan L, Deng X, Chovan L, Longenecker K, Judge R, Qin W, Brune M, Camp H, Frevert EU, Jacobson P, Link JT, Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. Epub 2006 Oct 7. PMID:17070044 Page seeded by OCA on Sun May 4 07:38:06 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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