Flagellin

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 9: Line 9:
<scene name='77/776389/Cv/2'>Fla and TLR5 binding interface is composed in part between the long helices of Fla and the ascending lateral surface of TLR5</scene><ref>PMID:22344444</ref>.
<scene name='77/776389/Cv/2'>Fla and TLR5 binding interface is composed in part between the long helices of Fla and the ascending lateral surface of TLR5</scene><ref>PMID:22344444</ref>.
 +
 +
== 3D Structures of flagellin ==
 +
[[Flagellin 3D structures]]
 +
</StructureSection>
</StructureSection>
== 3D Structures of flagellin ==
== 3D Structures of flagellin ==
Line 27: Line 31:
**[[5wjt]], [[5wju]], [[5wjv]], [[5wjw]], [[5wjx]], [[5wjy]], [[5wjz]] – BsFla – ''Bacillus subtilis'' – Cryo EM<br />
**[[5wjt]], [[5wju]], [[5wjv]], [[5wjw]], [[5wjx]], [[5wjy]], [[5wjz]] – BsFla – ''Bacillus subtilis'' – Cryo EM<br />
**[[2zbi]] – Fla - ''Sphingomonas''<br />
**[[2zbi]] – Fla - ''Sphingomonas''<br />
 +
**[[5z7q]] – Fla residues 54-229 – ''Bacillus cereus'' <br />
 +
**[[5z1l]] – Fla – ''Methanococcus maripaludis'' – Cryo EM<br />
* Flagellin complex
* Flagellin complex
Line 34: Line 40:
**[[3v47]] – Fla phase1 + TLR5 – ''Salmonella enterica''<br />
**[[3v47]] – Fla phase1 + TLR5 – ''Salmonella enterica''<br />
**[[5gy2]] – BsFla residues 54-230 + TLR5 <br />
**[[5gy2]] – BsFla residues 54-230 + TLR5 <br />
 +
**[[6gow]], [[5maw]] – BsFla + FliS <br />
**[[1ory]] – AaFla FliC residues 464-518 + FliS <br />
**[[1ory]] – AaFla FliC residues 464-518 + FliS <br />
**[[5yud]] – StFla + Naip5 <br />
**[[5yud]] – StFla + Naip5 <br />

Revision as of 06:36, 3 July 2019

Glycosylated flagellin (pink, yellow) complex with TLR5 (grey, green) (PDB code 3v47)

Drag the structure with the mouse to rotate

3D Structures of flagellin

Updated on 03-July-2019

References

  1. Zeng H, Carlson AQ, Guo Y, Yu Y, Collier-Hyams LS, Madara JL, Gewirtz AT, Neish AS. Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella. J Immunol. 2003 Oct 1;171(7):3668-74. PMID:14500664
  2. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 2001 Apr 26;410(6832):1099-103. PMID:11323673 doi:http://dx.doi.org/10.1038/35074106
  3. Yoon SI, Kurnasov O, Natarajan V, Hong M, Gudkov AV, Osterman AL, Wilson IA. Structural basis of TLR5-flagellin recognition and signaling. Science. 2012 Feb 17;335(6070):859-64. PMID:22344444 doi:10.1126/science.1215584

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Personal tools