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User:Ricardo Alberto Chiong Zevallos/Sandbox 1
From Proteopedia
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BMI1 is a ring finger protein that is component of a Polycomb group (PcG) multiprotein PRC1-like complex, which epigenetically repress regulatory genes, such as Hox genes, related to embryonic development and self-renewal of somatic stem-cells. BMI1 is central in the DNA damage repair, being the aberrant expression associated with numerous cancers and resistance to some types of chemotherapies. | BMI1 is a ring finger protein that is component of a Polycomb group (PcG) multiprotein PRC1-like complex, which epigenetically repress regulatory genes, such as Hox genes, related to embryonic development and self-renewal of somatic stem-cells. BMI1 is central in the DNA damage repair, being the aberrant expression associated with numerous cancers and resistance to some types of chemotherapies. | ||
| - | PcG PRC1-like is responsible for chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. BMI1 regulates the E3 ubiquitin-protein ligase activity of RNF2, which is also a protein component of the PcG PRC1-like complex. | + | PcG PRC1-like is responsible for chromatin remodeling and histone modification, mediating monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. BMI1 regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2, which is also a protein component of the PcG PRC1-like complex. In the complex, BMI1 and RING2 form a heterodimer and only RING2 interacts with UbcH5c, wich is a Ubiquitin Conjugating Enzyme E2. |
== Disease == | == Disease == | ||
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== Structure == | == Structure == | ||
| + | In the PRC1 complex, Bmi1 and Ring1b heterodimerize via their N-terminal RING domains, forming an active E3 ubiquitin ligase. | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
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[[http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 | BMI1 in NCBI]] | [[http://www.genecards.org/cgi-bin/carddisp.pl?gene=BMI1 | BMI1 in NCBI]] | ||
[[https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=648#gene-expression | BMI1 in NCBI]] | [[https://www.ncbi.nlm.nih.gov/gene?cmd=Retrieve&dopt=full_report&list_uids=648#gene-expression | BMI1 in NCBI]] | ||
| + | https://www.genecards.org/cgi-bin/carddisp.pl?gene=UBE2D3 | ||
| + | https://www.genenames.org/cgi-bin/genefamilies/set/58 | ||
| + | https://www.cellsignal.com/contents/resources-protein-domains-interactions/ring-protein-domain/domains-ring | ||
| + | http://www.ebi.ac.uk/interpro/entry/IPR001841 | ||
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https://drive.google.com/drive/folders/1l195aNuY6joOd74GKKxa-XWTRMBv_uWF?usp=sharing | https://drive.google.com/drive/folders/1l195aNuY6joOd74GKKxa-XWTRMBv_uWF?usp=sharing | ||
Revision as of 14:14, 1 June 2018
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
[| BMI1 in NCBI] [| BMI1 in NCBI] [| BMI1 in NCBI] https://www.genecards.org/cgi-bin/carddisp.pl?gene=UBE2D3 https://www.genenames.org/cgi-bin/genefamilies/set/58 https://www.cellsignal.com/contents/resources-protein-domains-interactions/ring-protein-domain/domains-ring http://www.ebi.ac.uk/interpro/entry/IPR001841
https://drive.google.com/drive/folders/1l195aNuY6joOd74GKKxa-XWTRMBv_uWF?usp=sharing
