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6aze
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog== | |
| - | + | <StructureSection load='6aze' size='340' side='right' caption='[[6aze]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6aze]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AZE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6AZE FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ML3:2-{[(2R)-2-AMINO-2-CARBOXYETHYL]SULFANYL}-N,N,N-TRIMETHYLETHANAMINIUM'>ML3</scene></td></tr> |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2f6j|2f6j]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6aze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aze OCA], [http://pdbe.org/6aze PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6aze RCSB], [http://www.ebi.ac.uk/pdbsum/6aze PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6aze ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BPTF_HUMAN BPTF_HUMAN]] Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chen, Z]] | [[Category: Chen, Z]] | ||
| + | [[Category: Ruthenburg, A J]] | ||
| + | [[Category: Bromodomain]] | ||
| + | [[Category: Gene regulation]] | ||
| + | [[Category: Histone reader]] | ||
| + | [[Category: Methyllsine analog]] | ||
| + | [[Category: Mla]] | ||
| + | [[Category: Phd-finger]] | ||
Revision as of 19:44, 19 September 2018
Crystal Structure of the BPTF PHD-bromodomain module bound to H3KC4me3 methyl lysine analog
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