2irv

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[[Image:2irv.gif|left|200px]]
[[Image:2irv.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2irv |SIZE=350|CAPTION= <scene name='initialview01'>2irv</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_2irv", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=LDA:LAURYL+DIMETHYLAMINE-N-OXIDE'>LDA</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= glpG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_2irv| PDB=2irv | SCENE= }}
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|RELATEDENTRY=[[2ic8|2IC8]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2irv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2irv OCA], [http://www.ebi.ac.uk/pdbsum/2irv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2irv RCSB]</span>
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}}
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'''Crystal structure of GlpG, a rhomboid intramembrane serine protease'''
'''Crystal structure of GlpG, a rhomboid intramembrane serine protease'''
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[[Category: Bibi, E.]]
[[Category: Bibi, E.]]
[[Category: Fass, D.]]
[[Category: Fass, D.]]
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[[Category: cavity]]
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[[Category: Cavity]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: ser-his dyad]]
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[[Category: Ser-his dyad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:47:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:47:40 2008''
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Revision as of 04:47, 4 May 2008

Image:2irv.gif

Template:STRUCTURE 2irv

Crystal structure of GlpG, a rhomboid intramembrane serine protease


Overview

Intramembrane proteases catalyze peptide bond cleavage of integral membrane protein substrates. This activity is crucial for many biological and pathological processes. Rhomboids are evolutionarily widespread intramembrane serine proteases. Here, we present the 2.3-A-resolution crystal structure of a rhomboid from Escherichia coli. The enzyme has six transmembrane helices, five of which surround a short TM4, which starts deep within the membrane at the catalytic serine residue. Thus, the catalytic serine is in an externally exposed cavity, which provides a hydrophilic environment for proteolysis. Our results reveal a mechanism to enable water-dependent catalysis at the depth of the hydrophobic milieu of the membrane and suggest how substrates gain access to the sequestered rhomboid active site.

About this Structure

2IRV is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Structural basis for intramembrane proteolysis by rhomboid serine proteases., Ben-Shem A, Fass D, Bibi E, Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):462-6. Epub 2006 Dec 26. PMID:17190827 Page seeded by OCA on Sun May 4 07:47:29 2008

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