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2isn

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[[Image:2isn.jpg|left|200px]]
[[Image:2isn.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2isn |SIZE=350|CAPTION= <scene name='initialview01'>2isn</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2isn", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+400'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+B+500'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+B+600'>AC3</scene>, <scene name='pdbsite=AC4:Pr+Binding+Site+For+Residue+B+422'>AC4</scene> and <scene name='pdbsite=AC5:Pr+Binding+Site+For+Residue+A+522'>AC5</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143 PP2Cc]</span>
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{{STRUCTURE_2isn| PDB=2isn | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2isn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2isn OCA], [http://www.ebi.ac.uk/pdbsum/2isn PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2isn RCSB]</span>
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}}
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'''Crystal structure of a phosphatase from a pathogenic strain Toxoplasma gondii'''
'''Crystal structure of a phosphatase from a pathogenic strain Toxoplasma gondii'''
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==About this Structure==
==About this Structure==
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2ISN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISN OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISN OCA].
==Reference==
==Reference==
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
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[[Category: Protein complex]]
 
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[[Category: Toxoplasma gondii]]
 
[[Category: Agarwal, R.]]
[[Category: Agarwal, R.]]
[[Category: Burley, S K.]]
[[Category: Burley, S K.]]
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[[Category: Swaminathan, S.]]
[[Category: Swaminathan, S.]]
[[Category: 8828z]]
[[Category: 8828z]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: new york structural genomix research consortium]]
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[[Category: New york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: Nysgxrc]]
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[[Category: pathogenic strain]]
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[[Category: Pathogenic strain]]
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[[Category: phosphatase]]
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[[Category: Phosphatase]]
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[[Category: praseodymium]]
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[[Category: Praseodymium]]
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[[Category: protein structure initiative]]
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[[Category: Protein structure initiative]]
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[[Category: psi-2]]
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[[Category: Psi-2]]
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[[Category: structural genomic]]
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[[Category: Structural genomic]]
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[[Category: sulfate]]
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[[Category: Sulfate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:49:10 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:48:00 2008''
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Revision as of 04:49, 4 May 2008

Image:2isn.jpg

Template:STRUCTURE 2isn

Crystal structure of a phosphatase from a pathogenic strain Toxoplasma gondii


Overview

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:18058037 Page seeded by OCA on Sun May 4 07:49:10 2008

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