2d8c

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==Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1==
==Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1==
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<StructureSection load='2d8c' size='340' side='right' caption='[[2d8c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2d8c' size='340' side='right'caption='[[2d8c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2d8c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2D8C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2d8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2D8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2D8C FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">9530058O11Rik ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">9530058O11Rik ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2d8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8c OCA], [http://pdbe.org/2d8c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2d8c RCSB], [http://www.ebi.ac.uk/pdbsum/2d8c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8c ProSAT], [http://www.topsan.org/Proteins/RSGI/2d8c TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2d8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2d8c OCA], [https://pdbe.org/2d8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2d8c RCSB], [https://www.ebi.ac.uk/pdbsum/2d8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2d8c ProSAT], [https://www.topsan.org/Proteins/RSGI/2d8c TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SMS1_MOUSE SMS1_MOUSE]] Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.<ref>PMID:16879426</ref> <ref>PMID:22580896</ref>
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[[https://www.uniprot.org/uniprot/SMS1_MOUSE SMS1_MOUSE]] Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecule in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types (By similarity). Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimuli such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide.<ref>PMID:16879426</ref> <ref>PMID:22580896</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Goroncy, A K]]
[[Category: Goroncy, A K]]

Revision as of 11:55, 3 February 2021

Solution structure of the sam-domain of mouse phosphatidyl ceramidecholinephosphotransferase 1

PDB ID 2d8c

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