2iw1

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[[Image:2iw1.gif|left|200px]]
[[Image:2iw1.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2iw1 |SIZE=350|CAPTION= <scene name='initialview01'>2iw1</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2iw1", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:U2f+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=U2F:URIDINE-5&#39;-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE'>U2F</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2iw1| PDB=2iw1 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iw1 OCA], [http://www.ebi.ac.uk/pdbsum/2iw1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iw1 RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS'''
'''CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS'''
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[[Category: Proctor, M.]]
[[Category: Proctor, M.]]
[[Category: Roberts, S.]]
[[Category: Roberts, S.]]
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[[Category: family gt-4]]
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[[Category: Family gt-4]]
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[[Category: glycosyltransferase]]
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[[Category: Glycosyltransferase]]
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[[Category: lipopolysaccharide biosynthesis]]
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[[Category: Lipopolysaccharide biosynthesis]]
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[[Category: lp]]
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[[Category: Lp]]
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[[Category: retaining]]
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[[Category: Retaining]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: udp-glucose]]
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[[Category: Udp-glucose]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:57:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:25 2008''
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Revision as of 04:57, 4 May 2008

Image:2iw1.gif

Template:STRUCTURE 2iw1

CRYSTAL STRUCTURE OF WAAG, A GLYCOSYLTRANSFERASE INVOLVED IN LIPOPOLYSACCHARIDE BIOSYNTHESIS


Overview

Glycosyltransferases (GTs) catalyze the synthesis of the myriad glycoconjugates that are central to life. One of the largest families is GT4, which contains several enzymes of therapeutic significance, exemplified by WaaG and AviGT4. WaaG catalyses a key step in lipopolysaccharide synthesis, while AviGT4, produced by Streptomyces viridochromogenes, contributes to the synthesis of the antibiotic avilamycin A. Here we present the crystal structure of both WaaG and AviGT4. The two enzymes contain two "Rossmann-like" (beta/alpha/beta) domains characteristic of the GT-B fold. Both recognition of the donor substrate and the catalytic machinery is similar to other retaining GTs that display the GT-B fold. Structural information is discussed with respect to the evolution of GTs and the therapeutic significance of the two enzymes.

About this Structure

2IW1 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Insights into the synthesis of lipopolysaccharide and antibiotics through the structures of two retaining glycosyltransferases from family GT4., Martinez-Fleites C, Proctor M, Roberts S, Bolam DN, Gilbert HJ, Davies GJ, Chem Biol. 2006 Nov;13(11):1143-52. PMID:17113996 Page seeded by OCA on Sun May 4 07:57:45 2008

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