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2dde

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Revision as of 07:05, 6 November 2019

Structure of cinnamycin complexed with lysophosphatidylethanolamine

Structural highlights

2dde is a 1 chain structure with sequence from Streptomyces griseoverticillatus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
NonStd Res:	, ,
Related:	1aj1, 1mqx, 1mqy, 1mqz, 1qow, 1w9n, 1wco, 2ktn, 2kto
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CINA_STRGV] Can act as inhibitor of the enzyme phospholipase A2, and of the angiotensin-converting enzyme. Shows inhibitory activities against herpes simplex virus and immunopotentiating activities. Its antimicrobial activities are not very pronounced.

Publication Abstract from PubMed

The three-dimensional structure of a complex of cinnamycin, a 19-amino acid residue immunopotentiator peptide, and lysophosphatidylethanolamine was determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and 26 A in length, excluding the acyl chain of the phospholipid. The peptide had a hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the head group of the ligand. Fitting of the head group to the hydrophobic pocket was so good that other than a glycerophosphoethanolamine head group would be unable to fit the pocket. The goodness of the fitting is compatible with the strict specificity of ligand binding of the peptide.

Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1.,Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K J Biochem. 1996 Feb;119(2):226-30. PMID:8882709^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hosoda K, Ohya M, Kohno T, Maeda T, Endo S, Wakamatsu K. Structure determination of an immunopotentiator peptide, cinnamycin, complexed with lysophosphatidylethanolamine by 1H-NMR1. J Biochem. 1996 Feb;119(2):226-30. PMID:8882709

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2dde"

@@ Line 1: / Line 1: @@
 ==Structure of cinnamycin complexed with lysophosphatidylethanolamine==
-<StructureSection load='2dde' size='340' side='right' caption='[[2dde]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2dde' size='340' side='right'caption='[[2dde]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2dde]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_griseoverticillatus Streptomyces griseoverticillatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2DDE FirstGlance]. <br>
@@ Line 24: / Line 24: @@
 __TOC__
 </StructureSection>
+[[Category: Large Structures]]
 [[Category: Streptomyces griseoverticillatus]]
 [[Category: Endo, S]]

2dde

From Proteopedia

Revision as of 07:05, 6 November 2019

Structure of cinnamycin complexed with lysophosphatidylethanolamine

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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