2iw5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2iw5.gif|left|200px]]
[[Image:2iw5.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2iw5 |SIZE=350|CAPTION= <scene name='initialview01'>2iw5</scene>, resolution 2.57&Aring;
+
The line below this paragraph, containing "STRUCTURE_2iw5", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2iw5| PDB=2iw5 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iw5 OCA], [http://www.ebi.ac.uk/pdbsum/2iw5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iw5 RCSB]</span>
+
-
}}
+
'''STRUCTURAL BASIS FOR COREST-DEPENDENT DEMETHYLATION OF NUCLEOSOMES BY THE HUMAN LSD1 HISTONE DEMETHYLASE'''
'''STRUCTURAL BASIS FOR COREST-DEPENDENT DEMETHYLATION OF NUCLEOSOMES BY THE HUMAN LSD1 HISTONE DEMETHYLASE'''
Line 33: Line 30:
[[Category: Yang, M.]]
[[Category: Yang, M.]]
[[Category: Yu, H.]]
[[Category: Yu, H.]]
-
[[Category: alternative splicing]]
+
[[Category: Alternative splicing]]
-
[[Category: chromatin demethylation]]
+
[[Category: Chromatin demethylation]]
-
[[Category: chromatin regulator]]
+
[[Category: Chromatin regulator]]
-
[[Category: coiled coil]]
+
[[Category: Coiled coil]]
-
[[Category: corest]]
+
[[Category: Corest]]
-
[[Category: fad]]
+
[[Category: Fad]]
-
[[Category: histone demethylase]]
+
[[Category: Histone demethylase]]
-
[[Category: host-virus interaction]]
+
[[Category: Host-virus interaction]]
-
[[Category: lsd1]]
+
[[Category: Lsd1]]
-
[[Category: nuclear protein]]
+
[[Category: Nuclear protein]]
-
[[Category: nucleosome]]
+
[[Category: Nucleosome]]
-
[[Category: oxidoreductase]]
+
[[Category: Oxidoreductase]]
-
[[Category: oxidoreductase/repressor complex]]
+
[[Category: Oxidoreductase/repressor complex]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: repressor]]
+
[[Category: Repressor]]
-
[[Category: transcription]]
+
[[Category: Transcription]]
-
[[Category: transcription regulation]]
+
[[Category: Transcription regulation]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:58:08 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:27 2008''
+

Revision as of 04:58, 4 May 2008

Image:2iw5.gif

Template:STRUCTURE 2iw5

STRUCTURAL BASIS FOR COREST-DEPENDENT DEMETHYLATION OF NUCLEOSOMES BY THE HUMAN LSD1 HISTONE DEMETHYLASE


Overview

Histone methylation regulates diverse chromatin-templated processes, including transcription. Many transcriptional corepressor complexes contain lysine-specific demethylase 1 (LSD1) and CoREST that collaborate to demethylate mono- and dimethylated H3-K4 of nucleosomes. Here, we report the crystal structure of the LSD1-CoREST complex. LSD1-CoREST forms an elongated structure with a long stalk connecting the catalytic domain of LSD1 and the CoREST SANT2 domain. LSD1 recognizes a large segment of the H3 tail through a deep, negatively charged pocket at the active site and possibly a shallow groove on its surface. CoREST SANT2 interacts with DNA. Disruption of the SANT2-DNA interaction diminishes CoREST-dependent demethylation of nucleosomes by LSD1. The shape and dimension of LSD1-CoREST suggest its bivalent binding to nucleosomes, allowing efficient H3-K4 demethylation. This spatially separated, multivalent nucleosome binding mode may apply to other chromatin-modifying enzymes that generally contain multiple nucleosome binding modules.

About this Structure

2IW5 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase., Yang M, Gocke CB, Luo X, Borek D, Tomchick DR, Machius M, Otwinowski Z, Yu H, Mol Cell. 2006 Aug 4;23(3):377-87. PMID:16885027 Page seeded by OCA on Sun May 4 07:58:08 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2iw5"
Personal tools