2iwm

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[[Image:2iwm.jpg|left|200px]]
[[Image:2iwm.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2iwm |SIZE=350|CAPTION= <scene name='initialview01'>2iwm</scene>, resolution 2.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2iwm", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Penicillin_amidase Penicillin amidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.11 3.5.1.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2iwm| PDB=2iwm | SCENE= }}
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|RELATEDENTRY=[[2pva|2PVA]], [[3pva|3PVA]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iwm OCA], [http://www.ebi.ac.uk/pdbsum/2iwm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iwm RCSB]</span>
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}}
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'''PRECURSOR MUTANT CYS1SER OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS'''
'''PRECURSOR MUTANT CYS1SER OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS'''
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[[Category: Dodson, G.]]
[[Category: Dodson, G.]]
[[Category: Suresh, C G.]]
[[Category: Suresh, C G.]]
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[[Category: antibiotic resistance]]
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[[Category: Antibiotic resistance]]
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[[Category: autoproteolysis]]
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[[Category: Autoproteolysis]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: penicillin]]
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[[Category: Penicillin]]
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[[Category: precursor]]
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[[Category: Precursor]]
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[[Category: zymogen]]
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[[Category: Zymogen]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:59:44 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:40 2008''
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Revision as of 04:59, 4 May 2008

Image:2iwm.jpg

Template:STRUCTURE 2iwm

PRECURSOR MUTANT CYS1SER OF PENICILLIN V ACYLASE FROM BACILLUS SPHAERICUS


Overview

The crystallization of three catalytically inactive mutants of penicillin V acylase (PVA) from Bacillus sphaericus in precursor and processed forms is reported. The mutant proteins crystallize in different primitive monoclinic space groups that are distinct from the crystal forms for the native enzyme. Directed mutants and clone constructs were designed to study the post-translational autoproteolytic processing of PVA. The catalytically inactive mutants will provide three-dimensional structures of precursor PVA forms, plus open a route to the study of enzyme-substrate complexes for this industrially important enzyme.

About this Structure

2IWM is a Single protein structure of sequence from Lysinibacillus sphaericus. Full crystallographic information is available from OCA.

Reference

Cloning, preparation and preliminary crystallographic studies of penicillin V acylase autoproteolytic processing mutants., Chandra PM, Brannigan JA, Prabhune A, Pundle A, Turkenburg JP, Dodson GG, Suresh CG, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jan 1;61(Pt, 1):124-7. Epub 2004 Dec 24. PMID:16508111 Page seeded by OCA on Sun May 4 07:59:44 2008

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