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Sandbox 7726
From Proteopedia
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== Disease == | == Disease == | ||
| - | This disease is primarily caused by the polyglutamine expansion in the ATXN1 protein. However, other factors are also required for the development of SCA1 neuropathology, including phosphorylation of Ser776 and nuclear localization. | + | This disease is primarily caused by the polyglutamine expansion in the ATXN1 protein. However, other factors are also required for the development of SCA1 neuropathology, including phosphorylation of Ser776 and nuclear localization.The synergy between these factors are not yet fully elucidated. |
== Relevance == | == Relevance == | ||
Revision as of 06:43, 5 June 2018
Protein-protein interaction between Ataxin-1 and Capicua
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References
- ↑ Kim E, Lu HC, Zoghbi HY, Song JJ. Structural basis of protein complex formation and reconfiguration by polyglutamine disease protein Ataxin-1 and Capicua. Genes Dev. 2013 Mar 15;27(6):590-5. doi: 10.1101/gad.212068.112. PMID:23512657 doi:http://dx.doi.org/10.1101/gad.212068.112
