2ix5

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[[Image:2ix5.gif|left|200px]]
[[Image:2ix5.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2ix5 |SIZE=350|CAPTION= <scene name='initialview01'>2ix5</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2ix5", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Fad+Binding+Site+For+Chain+D'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CAA:ACETOACETYL-COENZYME+A'>CAA</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-CoA_oxidase Acyl-CoA oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.3.6 1.3.3.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2ix5| PDB=2ix5 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ix5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix5 OCA], [http://www.ebi.ac.uk/pdbsum/2ix5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ix5 RCSB]</span>
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}}
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'''SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4 IN COMPLEX WITH ACETOACETYL-COA'''
'''SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4 IN COMPLEX WITH ACETOACETYL-COA'''
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[[Category: Mackenzie, J.]]
[[Category: Mackenzie, J.]]
[[Category: Pedersen, L.]]
[[Category: Pedersen, L.]]
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[[Category: acx4]]
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[[Category: Acx4]]
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[[Category: acyl-coa oxidase]]
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[[Category: Acyl-coa oxidase]]
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[[Category: beta-oxidation]]
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[[Category: Beta-oxidation]]
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[[Category: electron transfer]]
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[[Category: Electron transfer]]
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[[Category: fad]]
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[[Category: Fad]]
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[[Category: fatty acid metabolism]]
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[[Category: Fatty acid metabolism]]
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[[Category: flavin]]
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[[Category: Flavin]]
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[[Category: flavoprotein]]
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[[Category: Flavoprotein]]
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[[Category: glyoxysome]]
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[[Category: Glyoxysome]]
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[[Category: lipid metabolism]]
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[[Category: Lipid metabolism]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: peroxisome]]
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[[Category: Peroxisome]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:01:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:53 2008''
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Revision as of 05:01, 4 May 2008

Image:2ix5.gif

Template:STRUCTURE 2ix5

SHORT CHAIN SPECIFIC ACYL-COA OXIDASE FROM ARABIDOPSIS THALIANA, ACX4 IN COMPLEX WITH ACETOACETYL-COA


Overview

Plants produce a unique peroxisomal short chain-specific acyl-CoA oxidase (ACX4) for beta-oxidation of lipids. The short chain-specific oxidase has little resemblance to other peroxisomal acyl-CoA oxidases but has an approximately 30% sequence identity to mitochondrial acyl-CoA dehydrogenases. Two biochemical features have been linked to structural properties by comparing the structures of short chain-specific Arabidopsis thaliana ACX4 with and without a substrate analogue bound in the active site to known acyl-CoA oxidases and dehydrogenase structures: (i) a solvent-accessible acyl binding pocket is not required for oxygen reactivity, and (ii) the oligomeric state plays a role in substrate pocket architecture but is not linked to oxygen reactivity. The structures indicate that the acyl-CoA oxidases may encapsulate the electrons for transfer to molecular oxygen by blocking the dehydrogenase substrate interaction site with structural extensions. A small binding pocket observed adjoining the flavin adenine dinucleotide N5 and C4a atoms could increase the number of productive encounters between flavin adenine dinucleotide and O2.

About this Structure

2IX5 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Controlling electron transfer in Acyl-CoA oxidases and dehydrogenases: a structural view., Mackenzie J, Pedersen L, Arent S, Henriksen A, J Biol Chem. 2006 Oct 13;281(41):31012-20. Epub 2006 Aug 3. PMID:16887802 Page seeded by OCA on Sun May 4 08:01:23 2008

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