5vof

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'''Unreleased structure'''
 
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The entry 5vof is ON HOLD
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==DesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban==
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<StructureSection load='5vof' size='340' side='right' caption='[[5vof]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Krishnaswamy, S., Kumar, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5vof]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VOF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VOF FirstGlance]. <br>
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Description: DesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RIV:5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXOMORPHOLIN-4-YL)PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)THIOPHENE-2-CARBOXAMIDE'>RIV</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CFL:4-AMINO-1-(2-DEOXY-2-FLUORO-5-O-PHOSPHONO-BETA-D-ARABINOFURANOSYL)PYRIMIDIN-2(1H)-ONE'>CFL</scene>, <scene name='pdbligand=UFT:2-DEOXY-2-FLUOROURIDINE+5-(DIHYDROGEN+PHOSPHATE)'>UFT</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vof FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vof OCA], [http://pdbe.org/5vof PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vof RCSB], [http://www.ebi.ac.uk/pdbsum/5vof PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vof ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[http://omim.org/entry/227600 227600]]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN]] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Coagulation factor Xa]]
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[[Category: Krishnaswamy, S]]
[[Category: Kumar, S]]
[[Category: Kumar, S]]
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[[Category: Krishnaswamy, S]]
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[[Category: Aptamer]]
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[[Category: Blood coagulation]]
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[[Category: Hydrolase-hydrolase inhibitor-rna complex]]
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[[Category: Inhibitor]]
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[[Category: Serine protease]]

Revision as of 07:32, 14 June 2018

DesGla-XaS195A Bound to Aptamer 11F7t and Rivaroxaban

5vof, resolution 2.25Å

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