2ix8

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[[Image:2ix8.jpg|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2ix8", creates the "Structure Box" on the page.
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{{STRUCTURE_2ix8| PDB=2ix8 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ix8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ix8 OCA], [http://www.ebi.ac.uk/pdbsum/2ix8 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ix8 RCSB]</span>
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'''MODEL FOR EEF3 BOUND TO AN 80S RIBOSOME'''
'''MODEL FOR EEF3 BOUND TO AN 80S RIBOSOME'''
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[[Category: Pedersen, J S.]]
[[Category: Pedersen, J S.]]
[[Category: Spahn, C M.T.]]
[[Category: Spahn, C M.T.]]
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[[Category: acetylation]]
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[[Category: Acetylation]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: elongation factor]]
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[[Category: Elongation factor]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: protein biosynthesis]]
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[[Category: Protein biosynthesis]]
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[[Category: rna-binding]]
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[[Category: Rna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:01:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:49:58 2008''
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Revision as of 05:01, 4 May 2008

Image:2ix8.jpg

Template:STRUCTURE 2ix8

MODEL FOR EEF3 BOUND TO AN 80S RIBOSOME


Overview

Elongation factor eEF3 is an ATPase that, in addition to the two canonical factors eEF1A and eEF2, serves an essential function in the translation cycle of fungi. eEF3 is required for the binding of the aminoacyl-tRNA-eEF1A-GTP ternary complex to the ribosomal A-site and has been suggested to facilitate the clearance of deacyl-tRNA from the E-site. Here we present the crystal structure of Saccharomyces cerevisiae eEF3, showing that it consists of an amino-terminal HEAT repeat domain, followed by a four-helix bundle and two ABC-type ATPase domains, with a chromodomain inserted in ABC2. Moreover, we present the cryo-electron microscopy structure of the ATP-bound form of eEF3 in complex with the post-translocational-state 80S ribosome from yeast. eEF3 uses an entirely new factor binding site near the ribosomal E-site, with the chromodomain likely to stabilize the ribosomal L1 stalk in an open conformation, thus allowing tRNA release.

About this Structure

2IX8 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structure of eEF3 and the mechanism of transfer RNA release from the E-site., Andersen CB, Becker T, Blau M, Anand M, Halic M, Balar B, Mielke T, Boesen T, Pedersen JS, Spahn CM, Kinzy TG, Andersen GR, Beckmann R, Nature. 2006 Oct 12;443(7112):663-8. Epub 2006 Aug 23. PMID:16929303 Page seeded by OCA on Sun May 4 08:01:49 2008

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