2iz0

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[[Image:2iz0.gif|left|200px]]
[[Image:2iz0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2iz0 |SIZE=350|CAPTION= <scene name='initialview01'>2iz0</scene>, resolution 2.60&Aring;
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The line below this paragraph, containing "STRUCTURE_2iz0", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Peg+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATR:2&#39;-MONOPHOSPHOADENOSINE-5&#39;-DIPHOSPHATE'>ATR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RES:4-PHOSPHO-D-ERYTHRONOHYDROXAMIC+ACID'>RES</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphogluconate_dehydrogenase_(decarboxylating) Phosphogluconate dehydrogenase (decarboxylating)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.44 1.1.1.44] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2iz0| PDB=2iz0 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iz0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iz0 OCA], [http://www.ebi.ac.uk/pdbsum/2iz0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iz0 RCSB]</span>
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}}
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'''PEX INHIBITOR-HOME DATA'''
'''PEX INHIBITOR-HOME DATA'''
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Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates., Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN, FEBS J. 2007 Jan;274(1):275-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17222187 17222187]
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates., Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN, FEBS J. 2007 Jan;274(1):275-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17222187 17222187]
[[Category: Lactococcus lactis]]
[[Category: Lactococcus lactis]]
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[[Category: Phosphogluconate dehydrogenase (decarboxylating)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Hunter, W N.]]
[[Category: Hunter, W N.]]
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[[Category: Sundaramoorthy, R.]]
[[Category: Sundaramoorthy, R.]]
[[Category: 6-phosphogluconate dehydrogenase]]
[[Category: 6-phosphogluconate dehydrogenase]]
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[[Category: gluconate utilization]]
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[[Category: Gluconate utilization]]
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[[Category: nadp]]
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[[Category: Nadp]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: pentose phosphate pathway]]
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[[Category: Pentose phosphate pathway]]
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[[Category: pentose shunt]]
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[[Category: Pentose shunt]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:06:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:50:40 2008''
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Revision as of 05:06, 4 May 2008

Image:2iz0.gif

Template:STRUCTURE 2iz0

PEX INHIBITOR-HOME DATA


Overview

Crystal structures of recombinant Lactococcus lactis 6-phosphogluconate dehydrogenase (LlPDH) in complex with substrate, cofactor, product and inhibitors have been determined. LlPDH shares significant sequence identity with the enzymes from sheep liver and the protozoan parasite Trypanosoma brucei for which structures have been reported. Comparisons indicate that the key residues in the active site are highly conserved, as are the interactions with the cofactor and the product ribulose 5-phosphate. However, there are differences in the conformation of the substrate 6-phosphogluconate which may reflect distinct states relevant to catalysis. Analysis of the complex formed with the potent inhibitor 4-phospho-d-erythronohydroxamic acid, suggests that this molecule does indeed mimic the high-energy intermediate state that it was designed to. The analysis also identified, as a contaminant by-product of the inhibitor synthesis, 4-phospho-d-erythronamide, which binds in similar fashion. LlPDH can now serve as a model system for structure-based inhibitor design targeting the enzyme from Trypanosoma species.

About this Structure

2IZ0 is a Single protein structure of sequence from Lactococcus lactis. Full crystallographic information is available from OCA.

Reference

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates., Sundaramoorthy R, Iulek J, Barrett MP, Bidet O, Ruda GF, Gilbert IH, Hunter WN, FEBS J. 2007 Jan;274(1):275-86. PMID:17222187 Page seeded by OCA on Sun May 4 08:06:14 2008

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OCA

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