2j0b

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[[Image:2j0b.jpg|left|200px]]
[[Image:2j0b.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2j0b |SIZE=350|CAPTION= <scene name='initialview01'>2j0b</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2j0b", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Udp+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UDP:URIDINE-5&#39;-DIPHOSPHATE'>UDP</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/O-fucosylpeptide_3-beta-N-acetylglucosaminyltransferase O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.222 2.4.1.222] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2j0b| PDB=2j0b | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j0b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j0b OCA], [http://www.ebi.ac.uk/pdbsum/2j0b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j0b RCSB]</span>
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}}
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'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE'''
'''STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE'''
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[[Category: Conti, E.]]
[[Category: Conti, E.]]
[[Category: Jinek, M.]]
[[Category: Jinek, M.]]
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[[Category: developmental protein]]
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[[Category: Developmental protein]]
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[[Category: glycoprotein]]
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[[Category: Glycoprotein]]
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[[Category: glycosyltransferase]]
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[[Category: Glycosyltransferase]]
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[[Category: golgi apparatus]]
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[[Category: Golgi apparatus]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: notch signaling]]
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[[Category: Notch signaling]]
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[[Category: signal-anchor]]
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[[Category: Signal-anchor]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:09:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:51:16 2008''
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Revision as of 05:09, 4 May 2008

Image:2j0b.jpg

Template:STRUCTURE 2j0b

STRUCTURE OF THE CATALYTIC DOMAIN OF MOUSE MANIC FRINGE IN COMPLEX WITH UDP AND MANGANESE


Overview

Fringe proteins are beta1,3-N-acetylglucosaminyltransferases that modify Notch receptors, altering their ligand-binding specificity to regulate Notch signaling in development. We present the crystal structure of mouse Manic Fringe bound to UDP and manganese. The structure reveals amino acid residues involved in recognition of donor substrates and catalysis, and a putative binding pocket for acceptor substrates. Mutations of several invariant residues in this pocket impair Fringe activity in vivo.

About this Structure

2J0B is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural insights into the Notch-modifying glycosyltransferase Fringe., Jinek M, Chen YW, Clausen H, Cohen SM, Conti E, Nat Struct Mol Biol. 2006 Oct;13(10):945-6. Epub 2006 Sep 10. PMID:16964258 Page seeded by OCA on Sun May 4 08:09:32 2008

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