2j0m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2j0m.jpg|left|200px]]
[[Image:2j0m.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2j0m |SIZE=350|CAPTION= <scene name='initialview01'>2j0m</scene>, resolution 2.80&Aring;
+
The line below this paragraph, containing "STRUCTURE_2j0m", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:4st+Binding+Site+For+Chain+B'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=4ST:1,2,3,4-TETRAHYDROGEN-STAUROSPORINE'>4ST</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2j0m| PDB=2j0m | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j0m OCA], [http://www.ebi.ac.uk/pdbsum/2j0m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j0m RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE A TWO-CHAIN COMPLEX BETWEEN THE FERM AND KINASE DOMAINS OF FOCAL ADHESION KINASE.'''
'''CRYSTAL STRUCTURE A TWO-CHAIN COMPLEX BETWEEN THE FERM AND KINASE DOMAINS OF FOCAL ADHESION KINASE.'''
Line 31: Line 28:
[[Category: Lietha, D.]]
[[Category: Lietha, D.]]
[[Category: Schaller, M D.]]
[[Category: Schaller, M D.]]
-
[[Category: atp-binding]]
+
[[Category: Atp-binding]]
-
[[Category: cell migration]]
+
[[Category: Cell migration]]
-
[[Category: ferm]]
+
[[Category: Ferm]]
-
[[Category: focal adhesion]]
+
[[Category: Focal adhesion]]
-
[[Category: integrin signaling]]
+
[[Category: Integrin signaling]]
-
[[Category: kinase]]
+
[[Category: Kinase]]
-
[[Category: nucleotide-binding]]
+
[[Category: Nucleotide-binding]]
-
[[Category: phosphorylation]]
+
[[Category: Phosphorylation]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
[[Category: tyrosine-protein kinase]]
+
[[Category: Tyrosine-protein kinase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:10:24 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:51:26 2008''
+

Revision as of 05:10, 4 May 2008

Image:2j0m.jpg

Template:STRUCTURE 2j0m

CRYSTAL STRUCTURE A TWO-CHAIN COMPLEX BETWEEN THE FERM AND KINASE DOMAINS OF FOCAL ADHESION KINASE.


Overview

Appropriate tyrosine kinase signaling depends on coordinated sequential coupling of protein-protein interactions with catalytic activation. Focal adhesion kinase (FAK) integrates signals from integrin and growth factor receptors to regulate cellular responses including cell adhesion, migration, and survival. Here, we describe crystal structures representing both autoinhibited and active states of FAK. The inactive structure reveals a mechanism of inhibition in which the N-terminal FERM domain directly binds the kinase domain, blocking access to the catalytic cleft and protecting the FAK activation loop from Src phosphorylation. Additionally, the FERM domain sequesters the Tyr397 autophosphorylation and Src recruitment site, which lies in the linker connecting the FERM and kinase domains. The active phosphorylated FAK kinase adopts a conformation that is immune to FERM inhibition. Our biochemical and structural analysis shows how the architecture of autoinhibited FAK orchestrates an activation sequence of FERM domain displacement, linker autophosphorylation, Src recruitment, and full catalytic activation.

About this Structure

2J0M is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Structural basis for the autoinhibition of focal adhesion kinase., Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ, Cell. 2007 Jun 15;129(6):1177-87. PMID:17574028 Page seeded by OCA on Sun May 4 08:10:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j0m"
Personal tools