2ed0
From Proteopedia
(Difference between revisions)
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==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)== | ==Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)== | ||
| - | <StructureSection load='2ed0' size='340' side='right' caption='[[2ed0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2ed0' size='340' side='right'caption='[[2ed0]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2ed0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ED0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ED0 FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABI2 ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABI2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ed0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ed0 OCA], [https://pdbe.org/2ed0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ed0 RCSB], [https://www.ebi.ac.uk/pdbsum/2ed0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ed0 ProSAT], [https://www.topsan.org/Proteins/RSGI/2ed0 TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/ABI2_HUMAN ABI2_HUMAN]] May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA.<ref>PMID:7590236</ref> <ref>PMID:8649853</ref> <ref>PMID:10498863</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Human]] | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Abe, H]] | [[Category: Abe, H]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 11:59, 10 February 2021
Solution structure of the SH3 domain of Abl interactor 2 (Abelson interactor 2)
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Categories: Human | Large Structures | Abe, H | Kigawa, T | Miyamoto, K | Structural genomic | Saito, K | Tochio, N | Yokoyama, S | Coiled coil | Cytoskeleton | National project on protein structural and functional analyse | Nppsfa | Nuclear protein | Phosphorylation | Rsgi | Sh3 domain | Signaling protein
