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2ely

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==Solution structure of the third zf-C2H2 domain from human Zinc finger protein 224==
==Solution structure of the third zf-C2H2 domain from human Zinc finger protein 224==
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<StructureSection load='2ely' size='340' side='right' caption='[[2ely]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ely' size='340' side='right'caption='[[2ely]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ely]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ELY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ely]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELY FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF224 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF224 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ely FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ely OCA], [http://pdbe.org/2ely PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2ely RCSB], [http://www.ebi.ac.uk/pdbsum/2ely PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2ely ProSAT], [http://www.topsan.org/Proteins/RSGI/2ely TOPSAN]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ely FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ely OCA], [https://pdbe.org/2ely PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ely RCSB], [https://www.ebi.ac.uk/pdbsum/2ely PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ely ProSAT], [https://www.topsan.org/Proteins/RSGI/2ely TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN]] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
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[[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN]] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Hayashi, F]]
[[Category: Hayashi, F]]
[[Category: Kurosaki, C]]
[[Category: Kurosaki, C]]

Revision as of 12:13, 10 February 2021

Solution structure of the third zf-C2H2 domain from human Zinc finger protein 224

PDB ID 2ely

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