2j38

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2j38.jpg|left|200px]]
[[Image:2j38.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2j38 |SIZE=350|CAPTION= <scene name='initialview01'>2j38</scene>, resolution 2.10&Aring;
+
The line below this paragraph, containing "STRUCTURE_2j38", creates the "Structure Box" on the page.
-
|SITE= <scene name='pdbsite=AC1:Ca+Binding+Site+For+Chain+A'>AC1</scene>
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GS5:5-CHLORO-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}-1-BENZOTHIOPHENE-2-SULFONAMIDE'>GS5</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2j38| PDB=2j38 | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j38 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j38 OCA], [http://www.ebi.ac.uk/pdbsum/2j38 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j38 RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''
'''CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX'''
Line 30: Line 27:
[[Category: Senger, S.]]
[[Category: Senger, S.]]
[[Category: Watson, N S.]]
[[Category: Watson, N S.]]
-
[[Category: blood coagulation]]
+
[[Category: Blood coagulation]]
-
[[Category: calcium]]
+
[[Category: Calcium]]
-
[[Category: complex]]
+
[[Category: Complex]]
-
[[Category: egf-like domain]]
+
[[Category: Egf-like domain]]
-
[[Category: gamma- carboxyglutamic acid]]
+
[[Category: Gamma- carboxyglutamic acid]]
-
[[Category: gamma-carboxyglutamic acid]]
+
[[Category: Gamma-carboxyglutamic acid]]
-
[[Category: glycoprotein]]
+
[[Category: Glycoprotein]]
-
[[Category: hydrolase]]
+
[[Category: Hydrolase]]
-
[[Category: hydroxylation]]
+
[[Category: Hydroxylation]]
-
[[Category: polymorphism]]
+
[[Category: Polymorphism]]
-
[[Category: protease]]
+
[[Category: Protease]]
-
[[Category: serine protease]]
+
[[Category: Serine protease]]
-
[[Category: zymogen]]
+
[[Category: Zymogen]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:16:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:18 2008''
+

Revision as of 05:16, 4 May 2008

Image:2j38.jpg

Template:STRUCTURE 2j38

CRYSTAL STRUCTURE OF A HUMAN FACTOR XA INHIBITOR COMPLEX


Overview

Torsional scans of sulfonamide S-C bonds in small model systems of a series of arylsulfonamide factor Xa inhibitors were performed in order to investigate if conformational effects can help to rationalise the observed SAR. Computational results were in good agreement with the experimental data indicating that the sulfonamide conformation plays an important role in determining the activity in this particular series of factor Xa inhibitors.

About this Structure

2J38 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Arylsulfonamides: a study of the relationship between activity and conformational preferences for a series of factor Xa inhibitors., Senger S, Convery MA, Chan C, Watson NS, Bioorg Med Chem Lett. 2006 Nov 15;16(22):5731-5. Epub 2006 Sep 18. PMID:16982192 Page seeded by OCA on Sun May 4 08:16:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2j38"
Personal tools