2eo6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Solution structure of the SH2 domain from mouse B-cell linker protein BLNK==
==Solution structure of the SH2 domain from mouse B-cell linker protein BLNK==
-
<StructureSection load='2eo6' size='340' side='right' caption='[[2eo6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+
<StructureSection load='2eo6' size='340' side='right'caption='[[2eo6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2EO6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2eo6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EO6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EO6 FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Blnk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
+
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Blnk ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [http://pdbe.org/2eo6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [http://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2eo6 ProSAT], [http://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eo6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eo6 OCA], [https://pdbe.org/2eo6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eo6 RCSB], [https://www.ebi.ac.uk/pdbsum/2eo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eo6 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eo6 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE]] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref>
+
[[https://www.uniprot.org/uniprot/BLNK_MOUSE BLNK_MOUSE]] Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.<ref>PMID:9705962</ref> <ref>PMID:12761551</ref> <ref>PMID:18369315</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 23: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Lk3 transgenic mice]]
[[Category: Hayashi, F]]
[[Category: Hayashi, F]]

Revision as of 12:19, 10 February 2021

Solution structure of the SH2 domain from mouse B-cell linker protein BLNK

PDB ID 2eo6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2eo6"
Personal tools