2elh
From Proteopedia
(Difference between revisions)
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==Solution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PA== | ==Solution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PA== | ||
| - | <StructureSection load='2elh' size='340' side='right' caption='[[2elh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | + | <StructureSection load='2elh' size='340' side='right'caption='[[2elh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2elh]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2elh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drome Drome]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ELH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ELH FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dan ([ | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dan ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2elh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2elh OCA], [https://pdbe.org/2elh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2elh RCSB], [https://www.ebi.ac.uk/pdbsum/2elh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2elh ProSAT], [https://www.topsan.org/Proteins/RSGI/2elh TOPSAN]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [[https://www.uniprot.org/uniprot/DAN_DROME DAN_DROME]] Probable transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics; effector gene that acts downstream of homothorax (hth), Distal-less (Dll), cut (ct) and spineless (ss) genes to control differentiation of distal antennal structures.<ref>PMID:12571108</ref> <ref>PMID:17493605</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Drome]] | [[Category: Drome]] | ||
| + | [[Category: Large Structures]] | ||
[[Category: Harada, T]] | [[Category: Harada, T]] | ||
[[Category: Kigawa, T]] | [[Category: Kigawa, T]] | ||
Revision as of 12:11, 10 February 2021
Solution structure of the CENP-B N-terminal DNA-binding domain of fruit fly distal antenna CG11849-PA
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