2j48
From Proteopedia
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'''NMR STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF THE CIKA PROTEIN.''' | '''NMR STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF THE CIKA PROTEIN.''' | ||
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[[Category: Liwang, A.]] | [[Category: Liwang, A.]] | ||
[[Category: Zhang, X.]] | [[Category: Zhang, X.]] | ||
| - | [[Category: | + | [[Category: Circadian clock]] |
| - | [[Category: | + | [[Category: Histidine protein kinase]] |
| - | [[Category: | + | [[Category: Kinase]] |
| - | [[Category: | + | [[Category: Pseudo-receiver]] |
| - | [[Category: | + | [[Category: Response regulator]] |
| - | [[Category: | + | [[Category: Transferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:25 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 05:18, 4 May 2008
NMR STRUCTURE OF THE PSEUDO-RECEIVER DOMAIN OF THE CIKA PROTEIN.
Overview
The circadian input kinase (CikA) is a major element of the pathway that provides environmental information to the circadian clock of the cyanobacterium Synechococcus elongatus. CikA is a polypeptide of 754 residues and has three recognizable domains: GAF, histidine protein kinase, and receiver-like. This latter domain of CikA lacks the conserved phospho-accepting aspartyl residue of bona fide receiver domains and is thus a pseudo-receiver (PsR). Recently, it was shown that the PsR domain (1) attenuates the autokinase activity of CikA, (2) is necessary to localize CikA to the cell pole, and (3) is necessary for the destabilization of CikA in the presence of the quinone analog 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone (DBMIB). The solution structure of the PsR domain of CikA, CikAPsR, is presented here. A model of the interaction between the PsR domain and HPK portion of CikA provides a potential explanation for how the PsR domain attenuates the autokinase activity of CikA. Finally, a likely quinone-binding surface on CikAPsR is shown here.
About this Structure
2J48 is a Single protein structure of sequence from Synechococcus elongatus. Full crystallographic information is available from OCA.
Reference
NMR structure of the pseudo-receiver domain of CikA., Gao T, Zhang X, Ivleva NB, Golden SS, LiWang A, Protein Sci. 2007 Mar;16(3):465-75. PMID:17322531 Page seeded by OCA on Sun May 4 08:18:25 2008
