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2j47

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[[Image:2j47.gif|left|200px]]
[[Image:2j47.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2j47 |SIZE=350|CAPTION= <scene name='initialview01'>2j47</scene>, resolution 1.98&Aring;
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The line below this paragraph, containing "STRUCTURE_2j47", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Gdv+Binding+Site+For+Chain+A'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GDV:(5R,6R,7R,8S)-8-(ACETYLAMINO)-6,7-DIHYDROXY-5-(HYDROXYMETHYL)-N-PHENYL-1,5,6,7,8,8A-HEXAHYDROIMIDAZO[1,2-A]PYRIDINE-2-CARBOXAMIDE'>GDV</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-N-acetylhexosaminidase Beta-N-acetylhexosaminidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.52 3.2.1.52] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2j47| PDB=2j47 | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2j47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j47 OCA], [http://www.ebi.ac.uk/pdbsum/2j47 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2j47 RCSB]</span>
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}}
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'''BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR'''
'''BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR'''
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[[Category: Davies, G J.]]
[[Category: Davies, G J.]]
[[Category: Dennis, R J.]]
[[Category: Dennis, R J.]]
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[[Category: enzyme]]
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[[Category: Enzyme]]
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[[Category: gh84]]
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[[Category: Gh84]]
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[[Category: imidazole]]
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[[Category: Imidazole]]
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[[Category: inhibition]]
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[[Category: Inhibition]]
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[[Category: inhibitor]]
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[[Category: Inhibitor]]
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[[Category: o-glcnacase]]
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[[Category: O-glcnacase]]
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[[Category: pugnac]]
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[[Category: Pugnac]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 08:18:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:52:40 2008''
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Revision as of 05:18, 4 May 2008

Image:2j47.gif

Template:STRUCTURE 2j47

BACTEROIDES THETAIOTAOMICRON GH84 O-GLCNACASE IN COMPLEX WITH A IMIDAZOLE-PUGNAC HYBRID INHIBITOR


Overview

Synthesis of a PUGNAc-imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

About this Structure

2J47 is a Single protein structure of sequence from Bacteroides thetaiotaomicron. Full crystallographic information is available from OCA.

Reference

Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc-imidazole hybrid inhibitor., Shanmugasundaram B, Debowski AW, Dennis RJ, Davies GJ, Vocadlo DJ, Vasella A, Chem Commun (Camb). 2006 Nov 13;(42):4372-4. Epub 2006 Sep 29. PMID:17057847 Page seeded by OCA on Sun May 4 08:18:21 2008

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OCA

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