Proliferating Cell Nuclear Antigen

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Line 22: Line 22:
**[[3lx2]] - TkPCNA2<br />
**[[3lx2]] - TkPCNA2<br />
**[[3lox]], [[1plq]], [[1plr]], [[4yhr]], [[5t9d]] – yPCNA - yeast<br />
**[[3lox]], [[1plq]], [[1plr]], [[4yhr]], [[5t9d]] – yPCNA - yeast<br />
-
**[[3f1x]], [[3gpm]], [[3gpn]], [[3f1w]], [[4l60]], [[4l6p]] - yPCNA (mutant)<br />
+
**[[3f1x]], [[3gpm]], [[3gpn]], [[3f1w]], [[4l60]], [[4l6p]], [[6cx2]], [[6cx3]], [[6cx4]], [[5v7m]], [[5v7l]], [[5v7k]] - yPCNA (mutant)<br />
**[[3l0x]] - yPCNA N fragment + C fragment<br />
**[[3l0x]] - yPCNA N fragment + C fragment<br />
**[[3pge]] - yPCNA N fragment + SUMO-C fragment<br />
**[[3pge]] - yPCNA N fragment + SUMO-C fragment<br />
**[[1vym]], [[1w60]], [[3vkx]] – hPCNA - human<br />
**[[1vym]], [[1w60]], [[3vkx]] – hPCNA - human<br />
 +
**[[5mom]], [[5e0t]] – hPCNA (mutant)<br />
**[[5e0t]], [[5mom]] - hPCNA (mutant)<br />
**[[5e0t]], [[5mom]] - hPCNA (mutant)<br />
**[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br />
**[[2io4]] – SsPCNA B (mutant) + PCNA C - ''Sulfolobus solfataricus''<br />
Line 50: Line 51:
*PCNA complexes
*PCNA complexes
-
**[[1vyj]], [[1u76]], [[1u7b]] – hPCNA + peptide<br />
+
**[[1vyj]], [[1u76]], [[1u7b]], [[6cbi]], [[5yd8]], [[5yco]], [[5mlw]], [[5mlo]], [[5mav]], [[5iy4]], [[4ztd]], [[4rjf]] – hPCNA + peptide<br />
-
**[[4d2g]] – hPCNA + p15 peptide<br />
+
**[[5e0u]] - hPCNA (mutant) + peptide<br />
 +
**[[4d2g]], [[6gws]] – hPCNA + p15 peptide<br />
 +
**[[6e49]] – hPCNA + DNA helicase peptide<br />
 +
**[[6eht]] – hPCNA + p15 peptide + DNA<br />
 +
**[[5e0v]] - hPCNA + Flap structure-specific endonuclease peptide<br />
**[[4ztd]] - hPCNA + ubiquitin ligase peptide<br />
**[[4ztd]] - hPCNA + ubiquitin ligase peptide<br />
**[[3wgw]] – hPCNA + inhibitor<br />
**[[3wgw]] – hPCNA + inhibitor<br />
 +
**[[6gis]] – hPCNA + DNA<br />
**[[4rjf]] - hPCNA + p21 peptide<br />
**[[4rjf]] - hPCNA + p21 peptide<br />
**[[5e0u]] - hPCNA (mutant) + p21<br />
**[[5e0u]] - hPCNA (mutant) + p21<br />
Line 74: Line 80:
**[[3v60]], [[3v61]] – yPCNA (mutant) + ubiquitin-like protein SMT3<br />
**[[3v60]], [[3v61]] – yPCNA (mutant) + ubiquitin-like protein SMT3<br />
**[[3v62]] – yPCNA (mutant) + ubiquitin-like protein SMT3 + ATP-dependent DNA helicase SRS2<br />
**[[3v62]] – yPCNA (mutant) + ubiquitin-like protein SMT3 + ATP-dependent DNA helicase SRS2<br />
 +
**[[5zut]] – yPCNA + peptide <br />
**[[5jne]] - yPCNA (mutant) + SMT3 + E2<br />
**[[5jne]] - yPCNA (mutant) + SMT3 + E2<br />
**[[2izo]] - SsPCNA B + PCNA C + Flap structure-specific endonuclease<br />
**[[2izo]] - SsPCNA B + PCNA C + Flap structure-specific endonuclease<br />

Revision as of 08:27, 27 August 2018

Human proliferating cell nuclear antigen trimer (cyan, green, deeppink) complex with p15 peptide (yellow, magenta) (PDB entry 4d2g)

Drag the structure with the mouse to rotate

3D Structures of Proliferating Cell Nuclear Antigen

Updated on 27-August-2018

References

  1. Maga G, Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci. 2003 Aug 1;116(Pt 15):3051-60. PMID:12829735 doi:http://dx.doi.org/10.1242/jcs.00653
  2. Kullmann F, Fadaie M, Gross V, Knuchel R, Bocker T, Steinbach P, Scholmerich J, Ruschoff J. Expression of proliferating cell nuclear antigen (PCNA) and Ki-67 in dysplasia in inflammatory bowel disease. Eur J Gastroenterol Hepatol. 1996 Apr;8(4):371-9. PMID:8781908
  3. De Biasio A, de Opakua AI, Mortuza GB, Molina R, Cordeiro TN, Castillo F, Villate M, Merino N, Delgado S, Gil-Carton D, Luque I, Diercks T, Bernado P, Montoya G, Blanco FJ. Structure of p15(PAF)-PCNA complex and implications for clamp sliding during DNA replication and repair. Nat Commun. 2015 Mar 12;6:6439. doi: 10.1038/ncomms7439. PMID:25762514 doi:http://dx.doi.org/10.1038/ncomms7439

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Michal Harel, Alexander Berchansky, Lukáš Cakl, Joel L. Sussman

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