6ddz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target== | |
| - | + | <StructureSection load='6ddz' size='340' side='right' caption='[[6ddz]], [[Resolution|resolution]] 1.97Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6ddz]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DDZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DDZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5'-nucleotidase 5'-nucleotidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.5 3.1.3.5] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6ddz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ddz OCA], [http://pdbe.org/6ddz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ddz RCSB], [http://www.ebi.ac.uk/pdbsum/6ddz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ddz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] Autosomal recessive spastic paraplegia type 45. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:24482476</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/5NTC_HUMAN 5NTC_HUMAN]] May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: 5'-nucleotidase]] | ||
| + | [[Category: Ambesi-Impiombato, A]] | ||
[[Category: Carpenter, Z]] | [[Category: Carpenter, Z]] | ||
| + | [[Category: Dieck, C L]] | ||
| + | [[Category: Ferrando, A A]] | ||
[[Category: Forouhar, F]] | [[Category: Forouhar, F]] | ||
| + | [[Category: Kirschner-Schwabe, R]] | ||
[[Category: Lew, S]] | [[Category: Lew, S]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
| + | [[Category: Sanchez-Martin, M]] | ||
| + | [[Category: Seetharaman, J]] | ||
[[Category: Tong, L]] | [[Category: Tong, L]] | ||
| - | [[Category: Kirschner-Schwabe, R]] | ||
| - | [[Category: Ferrando, A.A]] | ||
| - | [[Category: Sanchez-Martin, M]] | ||
[[Category: Tzoneva, G]] | [[Category: Tzoneva, G]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| - | [[Category: | + | [[Category: Nesg]] |
| - | [[Category: | + | [[Category: Psi-biology]] |
Revision as of 07:16, 4 July 2018
Crystal structure of the double mutant (D52N/R238W) of NT5C2-537X in the active state, Northeast Structural Genomics Target
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