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6dih

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'''Unreleased structure'''
 
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The entry 6dih is ON HOLD until Paper Publication
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==Crystal structure of Tdp1 catalytic domain in complex with Sigma Aldrich compound PH004941==
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<StructureSection load='6dih' size='340' side='right'caption='[[6dih]], [[Resolution|resolution]] 1.78&Aring;' scene=''>
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Authors: Lountos, G.T., Zhao, X.Z., Kiselev, E., Tropea, J.E., Needle, D., Burke Jr., T.R., Pommier, Y., Waugh, D.S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6dih]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DIH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DIH FirstGlance]. <br>
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Description: Crystal structure of Tdp1 catalytic domain in complex with Sigma Aldrich compound PH004941
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GJS:4-hydroxybenzene-1,2-dicarboxylic+acid'>GJS</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dih OCA], [http://pdbe.org/6dih PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dih RCSB], [http://www.ebi.ac.uk/pdbsum/6dih PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dih ProSAT]</span></td></tr>
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[[Category: T.R]]
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</table>
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[[Category: Pommier, Y]]
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== Disease ==
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[[Category: Waugh, D.S]]
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[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] Defects in TDP1 are the cause of spinocerebellar ataxia autosomal recessive with axonal neuropathy (SCAN1) [MIM:[http://omim.org/entry/607250 607250]]. SCAN1 is an autosomal recessive cerebellar ataxia (ARCA) associated with peripheral axonal motor and sensory neuropathy, distal muscular atrophy, pes cavus and steppage gait as seen in Charcot-Marie-Tooth neuropathy. All affected individuals have normal intelligence.<ref>PMID:16141202</ref> <ref>PMID:15647511</ref> <ref>PMID:12244316</ref> <ref>PMID:17948061</ref> <ref>PMID:15920477</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/TYDP1_HUMAN TYDP1_HUMAN]] DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate.<ref>PMID:12023295</ref> <ref>PMID:15111055</ref> <ref>PMID:15811850</ref> <ref>PMID:16141202</ref> <ref>PMID:22822062</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Burke, T R]]
[[Category: Kiselev, E]]
[[Category: Kiselev, E]]
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[[Category: Zhao, X.Z]]
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[[Category: Lountos, G T]]
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[[Category: Tropea, J.E]]
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[[Category: Burke Jr]]
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[[Category: Needle, D]]
[[Category: Needle, D]]
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[[Category: Lountos, G.T]]
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[[Category: Pommier, Y]]
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[[Category: Tropea, J E]]
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[[Category: Waugh, D S]]
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[[Category: Zhao, X Z]]
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[[Category: Fragment-based drug design]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]

Revision as of 06:04, 29 May 2019

Crystal structure of Tdp1 catalytic domain in complex with Sigma Aldrich compound PH004941

PDB ID 6dih

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